Search Results - pharmaceutical

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Biodegradable Hyperbranched Polymer

Executive Summary Hyperbranched polymers are attractive due to unique structures, low viscosity, good solubility and a large number of functional end groups. However, because they are non linear polymers, they can be difficult to synthesize to high conversion without gelling. MSU and CMU researchers have developed a new hyperbranched polymer that is...
Published: 4/30/2024   |   Inventor(s): Patrick Smith, Bobby Howell, Tracy (Cuiwei) Zhang
Keywords(s):   Category(s): Advanced Materials, Agricultural, Pharmaceutical

Process for producing a Cyano ring-substituted Arene borane

Executive Summary In the pharmaceutical industry, organoboron complexes are key building blocks for drug manufacturing, versatile reagents for high-throughput parallel synthesis in drug discovery and exhibit some useful and unique biological activities. However, conventional synthesis routes can be complex and involve undesirable reagents. MSU researchers...
Published: 4/1/2024   |   Inventor(s): Milton Smith, Iii, Robert Maleczka, Ghayoor Chotana
Keywords(s):   Category(s): Chemicals, Pharmaceutical

Biocatalysis of Bioactive Taxanes

Executive Summary Chemotherapy drugs are critical for effective patient cancer care. Unfortunately, the pharmaceutical industry has encountered several instances where it has not been able to supply sufficient quantities of important chemotherapy drugs due to manufacturing problems. Michigan State University researchers have discovered a novel, faster...
Published: 10/2/2023   |   Inventor(s): Kevin Walker
Keywords(s):   Category(s): Medical, Pharmaceutical

Biosynthetic Route to Phloroglucinol Synthesis

Executive Summary: Phloroglucinol (1,3,5 trihydroxybenzene) is used in the production of a plethora of applications such as explosive or propellant compounds, medicaments, cosmetics, dyes, and others which make it such a sought-after resource. However, Phloroglucinol is difficult to synthesize by chemical synthesis and alternative routes are desired....
Published: 8/10/2023   |   Inventor(s): John Frost
Keywords(s):   Category(s): Chemicals, Pharmaceutical

Pyruvate-Based Pathway for Synthesis of 3-dehydroshikimate

Figure 1: (a) carbohydrate phosphotransferase; (b) KDPGal aldose, D-erythrose 4-phosphate; (c) DAHP synthase, D-erythrose 4-phosphate; (d) shikimate pathway enzymes. Executive Summary: 3-dehydroshikimate, a highly versatile compound that is currently limitedly produced, is used in supporting the creation of novel treatments of influenza...
Published: 8/10/2023   |   Inventor(s): John Frost
Keywords(s):   Category(s): Chemicals, Pharmaceutical

Extracellular Vesicle Library for Drug Screening

­ Executive Summary The body’s natural transporter, Extracellular vesicles (EVs), have gained recent attention for their potential as targeted drug delivery vehicles with low immunogenic response. Properly designing the surface allows EVs to deliver therapeutic payloads (protein, RNA, nanoparticle, small molecule, etc.) to a target organ....
Published: 10/16/2023   |   Inventor(s): Christopher Contag, Masako Harada
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Hybrid Gelatin Methacryloyl-Silver Bioactive Glass Bioink

­Executive Summary Three dimensional (3D) bioprinting is an emerging field that involves producing tissue structures with 3D printing techniques. Examples include bone tissue/fillers, synthetic skin, scaffolds for drug delivery and tissues for dental repair. Common 3D bioprinting methods include extrusion, stereolithography and microfluidics-based...
Published: 4/7/2023   |   Inventor(s): Nureddin Shammakhi, Xanthippi Chatzistavrou
Keywords(s):   Category(s): Medical, Advanced Materials, Nanotechnology, Pharmaceutical

Microfluidic Apparatus For Respirometry

Executive Summary Cellular respiration is a set of metabolic processes responsible for the conversion of chemical energy in all aerobic organisms. In animal and plant cells this takes place in the mitochondria where food is broken down to CO2 and strongly reducing compounds. Energy released upon oxidation of the latter by molecular oxygen via a chain...
Published: 2/17/2023   |   Inventor(s): Denis Proshlyakov, Julia Busik
Keywords(s):   Category(s): Medical, Devices, Pharmaceutical, Test and Measurement, Biotechnology

Antibacterial Silicate Glass-Ceramic Filament for 3D Printing Bone Materials

INTRODUCTION The use of 3D printed porous scaffolds provides a multi-dimensional template that closely mimics the native structure of bone. This is beneficial for creating ideal conditions for bone tissue regeneration. Silicate bioactive glass-ceramics are inherently bioconductive and bioinductive, making them ideal for tissue regeneration. DESCRIPTION...
Published: 8/20/2022   |   Inventor(s): Aljoscha Roch, Xanthippi Chatzistavrou
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Therapeutic for Tissue Healing and Resistive Bacteria

INTRODUCTION Healing infected tissue and combating resistant bacteria are significant clinical challenges. Antibiotic-based therapies are increasingly unsuccessful due to the ability of pathogens to develop resistance. Methicillin resistant Staphylococcus aureus (MRSA), for example, is a leading cause of many infections, including skin and soft tissue...
Published: 4/11/2024   |   Inventor(s): Xanthippi Chatzistavrou, Neal Hammer
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical
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