Search Results - christopher+contag

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Polyethylene Implants with Controlled Immune Response

Executive Summary Polyethylene is commonly used as a material for medical implants such as total joint replacements. Unfortunately, polyethylene wear particles can promote adverse host immune responses in patients, which may require secondary revision surgery. MSU researchers have recently discovered that metabolic reprogramming and altered bioenergetics...
Published: 9/18/2024   |   Inventor(s): Christopher Contag, Stuart Goodman, Chima Maduka
Keywords(s):   Category(s): Medical

Synthetic Implants with Controlled Immune Response

­ Executive Summary Polymers such as polylactic acid (PLA) are commonly used as bioabsorbable materials for implants. Unfortunately, degradation products from these often promote adverse host immune responses in patients, which may require a secondary medical intervention such as surgery to remove the implant. To attempt to counter this, some...
Published: 9/18/2024   |   Inventor(s): Chima Maduka, Christopher Contag
Keywords(s):   Category(s): Medical

Extracellular Vesicle Library for Drug Screening

­ Executive Summary The body’s natural transporter, Extracellular vesicles (EVs), have gained recent attention for their potential as targeted drug delivery vehicles with low immunogenic response. Properly designing the surface allows EVs to deliver therapeutic payloads (protein, RNA, nanoparticle, small molecule, etc.) to a target organ....
Published: 10/16/2023   |   Inventor(s): Christopher Contag, Masako Harada
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical