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Surface TSPO in blood cells: Biomarker of peripheral and brain inflammation

INTRODUCTIONTranslocator Protein 18kDa (TSPO) is a nuclear encoded outer mitochondrial membrane protein that is ubiquitously expressed by most host cells. Initially, TSPO was a diazepam target, but it has also been referred to as an ‘orphan protein searching for a function’. Since the generation of these knockouts, TSPO has been determined...
Published: 8/10/2020   |   Inventor(s): Norbert Kaminski, Robert Crawford, Lance Blevins
Keywords(s):   Category(s): Medical, Biotechnology, Test and Measurement

Small Molecule Inhibitors For The Treatment Of Proteinopathies

INTRODUCTIONProtein aggregation that leads to plaque formation is a contributor in many degenerative diseases including Alzheimer’s, Parkinson’s, Type 2 diabetes, and other amyloidosis diseases. Once these plaques are formed, they are extremely difficult to degrade. Breakdown and even inhibition of oligomers before formation of these plaques...
Published: 5/6/2020   |   Inventor(s): Jessica Fortin
Keywords(s):   Category(s): Medical, Chemicals, Pharmaceutical

New Compounds to Treat, Detect and Prevent Congenital Heart Disease

Executive Summary:Congenital heart defects (CHD) are the most common type of congenital defects in humans. It affects 1% of infants born each year. CHD can be caused by environmental exposures as well as having a genetic component to the disease. Studies have shown ~400 genes that are associated with CHD. However, 60% of the time the cause for these...
Published: 5/4/2020   |   Inventor(s): Aitor Aguirre
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical, Therapeutic

Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy

Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...

Flexible ECoG Electrode Array

Executive SummaryScaling ECoG arrays to whole-brain arrays or higher channel count with an intracranial chip is an area of active research, crucial to brain-machine interfaces that may define future technological advances. One barrier to scaling ECoG recording systems to high channel count (more precise and localized data) is the need for DC offset...
Published: 1/23/2019   |   Inventor(s): Ehsan Ashoori, Andrew Mason, Heyu Yin
Keywords(s):   Category(s): Medical

Immunomodulation Strategy for Enhancing Memory T Lymphocyte Immune Responses

IntroductionCytotoxic T cells (T cells) are a type of immune cell that provide immunological protection by destroying cells that are perceived as abnormal. T cell exhaustion or inhibition is often observed in patients with chronic viral infections or cancer, resulting in a decreased ability of the patient to overcome such diseases. One strategy to enhance...
Published: 12/28/2018   |   Inventor(s): Andrea Amalfitano, Yasser Aldhamen
Keywords(s):   Category(s): Medical

Pre-Treatment Method for Metals Determination in Aqueous Samples

Executive SummaryPractical detection of heavy metals in aqueous samples is a challenge for many testing and monitoring stations around the world. Heavy metal poisoning is the cause of thousands of deaths and disabilities. Specifically, metals including lead, arsenic, cadmium, and mercury have a direct impact on global health and are listed as four of...
Published: 12/10/2018   |   Inventor(s): Cory Rusinek, Michael Becker, Thomas Schuelke, Mary Ensch
Keywords(s):   Category(s): Medical, Biotechnology, Test and Measurement

Improving Pharmacokinetics and Efficacy of DFMO

Executive SummaryFor many years, the drug difluoromethylornithine (DFMO) has been shown to display chemopreventive and therapeutic properties with recent successes in the treatment of patients with high-risk neuroblastoma (NB) and colorectal cancer. In a non-cancer setting, this FDA-approved drug cures 95% of patients with West African sleeping sickness...
Published: 9/17/2018   |   Inventor(s): Andre Bachmann, Thomas Dowling
Keywords(s):   Category(s): Medical, Pharmaceutical

System for Identifying Brain Functional Area

Executive SummaryMagnetic Resonance Imaging, or MRI, has revolutionized non-invasive diagnostic methods used in modern medicine. Furthermore, functional MRI (fMRI) has allowed researchers and technicians to observe neuron activity directly by monitoring blood oxygen levels within small areas of the brain. However, steady states of activity must be established...
Published: 9/13/2018   |   Inventor(s): Jie Huang
Keywords(s):   Category(s): Medical, Biotechnology, Computer Software, Data Processing/Analysis

Prediction of Abdominal Aortic Aneurysm Expansion using Bayesian Calibration

Executive SummaryEnsuring that surgeries for Abdominal Aortic Aneurysms (AAA) are performed at the appropriate time is important to reduce the high mortality rates associated with this serious disease. During the past decade, a computational platform called a Growth & Remodeling (G&R) model has been developed to aid in this process. MSU researchers...
Published: 8/30/2018   |   Inventor(s): Seungik Baek, Tapabrata Maiti, Chae Young Lim, Jongeun Choi, Liangliang Zhang, Justin Mrkva
Keywords(s):   Category(s): Medical, Computer Software, Data Processing/Analysis
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