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Hybrid Gelatin Methacryloyl-Silver Bioactive Glass Bioink

­Executive Summary Three dimensional (3D) bioprinting is an emerging field that involves producing tissue structures with 3D printing techniques. Examples include bone tissue/fillers, synthetic skin, scaffolds for drug delivery and tissues for dental repair. Common 3D bioprinting methods include extrusion, stereolithography and microfluidics-based...
Published: 11/9/2021   |   Inventor(s): Nureddin Shammakhi, Xanthippi Chatzistavrou
Keywords(s):   Category(s): Medical, Advanced Materials, Nanotechnology, Pharmaceutical

Recombinant Protein for Rare Earth Element Binding

Executive Summary Rare earth elements (REEs) are essential materials used in advanced technologies such as electronics, process catalysts, magnets, batteries and MRI contrast agents. Although used in small quantities for each application, they end up in surface water and soil during mining, processing and waste disposal. This presents growing environmental...
Published: 10/29/2021   |   Inventor(s): Harvey Lee, Connor Grady, Assaf Gilad
Keywords(s):   Category(s): Medical, Biotechnology, Environment, Test and Measurement

Microfluidic Apparatus For Respirometry

Executive Summary Cellular respiration is a set of metabolic processes responsible for the conversion of chemical energy in all aerobic organisms. In animal and plant cells this takes place in the mitochondria where food is broken down to CO2 and strongly reducing compounds. Energy released upon oxidation of the latter by molecular oxygen via a chain...
Published: 10/20/2021   |   Inventor(s): Denis Proshlyakov, Julia Busik
Keywords(s):   Category(s): Medical, Devices, Pharmaceutical, Test and Measurement, Biotechnology

A Compact Design for Wireless Powered Resistive Senor

COMPACT DESIGN FOR WIRELESS POWERED RESISTIVE SENSORSVALUE PROPOSITIONWireless sensors are used to measure different parameters that could not previously be measured. Many wireless sensors on the market today use inductance to measure parameters but there are limited measures that can be done using inductance. Resistive measurements rely on a resistive...
Published: 6/30/2021   |   Inventor(s): Chunqi Qian, Wei Qian
Keywords(s):   Category(s): Medical, Devices, Test and Measurement

Development of an Artificial Intelligence Analysis Method for Magnetic Particle Imaging Using a Machine Learning Algorithm

Development of an artificial intelligence analysis method for magnetic particle imaging using a machine learning algorithm. iNTRODUCTION A magnetic particle imaging (MPI) device uses a changing magnetic field to cause superparamagnetic iron oxide (SPIO) nanoparticles to produce a signal upon exposure. The MPI device then detects these signals and...
Published: 6/15/2021   |   Inventor(s): Ping Wang, Hasaan Hayat, Jinda Fan
Keywords(s):   Category(s): Medical, Computer Software, Data Processing/Analysis

Antibacterial Silicate Glass-Ceramic Filament for 3D Printing Bone Materials

INTRODUCTION The use of 3D printed porous scaffolds provides a multi-dimensional template that closely mimics the native structure of bone. This is beneficial for creating ideal conditions for bone tissue regeneration. Silicate bioactive glass-ceramics are inherently bioconductive and bioinductive, making them ideal for tissue regeneration. DESCRIPTION...
Published: 6/14/2021   |   Inventor(s): Aljoscha Roch NO LONGER AT MSU, Xanthippi Chatzistavrou
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Therapeutic for Tissue Healing and Resistive Bacteria

INTRODUCTION Healing infected tissue and combating resistant bacteria are significant clinical challenges. Antibiotic-based therapies are increasingly unsuccessful due to the ability of pathogens to develop resistance. Methicillin resistant Staphylococcus aureus (MRSA), for example, is a leading cause of many infections, including skin and soft tissue...
Published: 6/14/2021   |   Inventor(s): Xanthippi Chatzistavrou, Neal Hammer
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Surface TSPO in blood cells: Biomarker of peripheral and brain inflammation

INTRODUCTIONTranslocator Protein 18kDa (TSPO) is a nuclear encoded outer mitochondrial membrane protein that is ubiquitously expressed by most host cells. Initially, TSPO was a diazepam target, but it has also been referred to as an ‘orphan protein searching for a function’. Since the generation of these knockouts, TSPO has been determined...
Published: 8/10/2020   |   Inventor(s): Norbert Kaminski, Robert Crawford, Lance Blevins
Keywords(s):   Category(s): Medical, Biotechnology, Test and Measurement

Small Molecule Inhibitors For The Treatment Of Proteinopathies

INTRODUCTIONProtein aggregation that leads to plaque formation is a contributor in many degenerative diseases including Alzheimer’s, Parkinson’s, Type 2 diabetes, and other amyloidosis diseases. Once these plaques are formed, they are extremely difficult to degrade. Breakdown and even inhibition of oligomers before formation of these plaques...
Published: 5/6/2020   |   Inventor(s): Jessica Fortin
Keywords(s):   Category(s): Medical, Chemicals, Pharmaceutical

Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy

Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...
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