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A Novel Enzyme from Solanum Habrochaites that Synthesizes Sesquiterpenes

IntroductionZingiberene is a sesquiterpene produced by many plant species including ginger, turmeric, cultivated tomato, and its wild relatives. It is synthesized at particularly high levels in the trichomes of certain accessions of the wild tomato species Solanum habrochaites and is a potent insect repellent. The identification of a gene from S. habrochaites...
Published: 8/22/2023   |   Inventor(s): Cornelius Barry, Eliana Gonzales-Vigil
Keywords(s): Insect Resistance, Terpene, Transgenic Crops Category(s): Biotechnology, Agriculture

Rapid Point of Care Detection of Tuberculosis

Executive Summary Tuberculosis (TB) remains one of the major causes of death from a single infectious agent worldwide, affecting both humans and livestock. Pulmonary TB can be currently diagnosed by various methods including chest radiography, sputum smear microscopy, nucleic acid amplification and cultivation of Mycobacterium tuberculosis (Mtb). However,...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja
Keywords(s):   Category(s): Medical, Biotechnology, Veterinary

Synthetic Bacterial Microcompartment Shell Proteins Derived by Circular Permutation and/or Genetic Fusion

INTRODUCTION Bacterial microcompartments (BMCs) are organelles used by various bacteria to encapsulate metabolic pathways into a proteinaceous shell. BMCs serve as scaffolds to organize encapsulated enzymes and as physical boundaries to reduce diffusive loss of volatile or toxic intermediates and restrict crosstalk with cytosolic biosynthetic pathways....
Published: 4/7/2023   |   Inventor(s): Cheryl Kerfeld, Bryan Ferlez, Markus Sutter, Andrew Hagen, Nancy Sloan
Keywords(s):   Category(s): Biotechnology, Energy, Chemicals, Environmental, Manufacturing Equipment

Electrically Active Magnetic Nanoparticle-based Biosensors

Executive Summary Harmful microbes are present in various sources including water, food, plants, and through human-to-human transmission. The ability to detect them rapidly at a low cost is important to protecting the health and safety of humans and animals and the security of food chains. MSU researchers have developed novel nanoparticle-based biosensors...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja, Sudeshna Pal, Emma Setterington
Keywords(s): Biosensors, Nanomagnetic, Pathogen, Polyaniline Category(s): Biotechnology, Test and Measurement, Devices

Bioluminescent Dopamine and Glutamate Sensors

­ Executive Summary Genetically encoded optical sensors and advancements in microscopy have revolutionized the scientific toolbox used for answering complex biological questions especially in terms of studying brain activity. However, there remains a need to develop new tools for reporting neuronal activity in vivo within deeper structures. MSU...
Published: 2/17/2023   |   Inventor(s): Eric Petersen
Keywords(s):   Category(s): Medical, Biotechnology

Extracellular Vesicle Library for Drug Screening

­ Executive Summary The body’s natural transporter, Extracellular vesicles (EVs), have gained recent attention for their potential as targeted drug delivery vehicles with low immunogenic response. Properly designing the surface allows EVs to deliver therapeutic payloads (protein, RNA, nanoparticle, small molecule, etc.) to a target organ....
Published: 10/16/2023   |   Inventor(s): Christopher Contag, Masako Harada
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Gold Nanoparticle Biosensors

Executive Summary Harmful microbes are present in a variety of sources including water, food, plants, and through human-to-human transmission. The ability to detect them rapidly at low cost is important to protecting the health and safety of humans and animals and the security of food chains. MSU researchers have developed novel gold (Au) nanoparticle...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja, Hanna Miller, Michael Anderson, Edith Torres-Chavolla
Keywords(s):   Category(s): Medical, Biotechnology, Food Science and Nutrition

Magnetic Nanoparticles, Magnetically Activated Cell Enrichment, and Biosensing

der-collapse: collapse; } Executive Summary Harmful microbes are present in a variety of sources including water, food, plants, environment, and through human-to-human transmission. The ability to detect them rapidly at low cost is important to protecting the health and safety of humans and animals and the security of food chains. MSU researchers...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja
Keywords(s):   Category(s): Medical, Biotechnology, Food Science and Nutrition

Enzymatic Route for Production of 3-Hydroxypropionic acid (3-HP)

­ Executive Summary Most organic (carbon-containing) chemicals used today are derived from petroleum or natural gas. Increasingly, companies are looking for alternative carbon sources to meet a growing demands for sustainability. 3-Hydroxypropionic acid (3-HP) is an intermediate that can be transformed into many important chemicals used in a variety...
Published: 2/17/2023   |   Inventor(s): Karen Draths, James Geiger, Amaya Sirinimal Mathes Hewage, Hadi Gavgani
Keywords(s):   Category(s): Chemicals, Biotechnology

Recombinant Protein for Rare Earth Element Binding

Executive Summary Rare earth elements (REEs) are essential materials used in advanced technologies such as electronics, process catalysts, magnets, batteries and MRI contrast agents. Although used in small quantities for each application, they end up in surface water and soil during mining, processing and waste disposal. This presents growing environmental...
Published: 4/7/2023   |   Inventor(s): Harvey Lee, Connor Grady, Assaf Gilad
Keywords(s):   Category(s): Medical, Biotechnology, Environment, Test and Measurement
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