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Evolution Of Models To Predict Protein Function Using Genetic Programming

INTRODUCTIONGenetic Programming (GP) follows the concept put forth by Darwin – “Survival of the Fittest”. Species that evolve and adapt in response to the environment are more likely to survive. GP evolves models that can optimize peptides and proteins for variety of applications. It requires only basic understanding in protein engineering....

New Compounds to Treat, Detect and Prevent Congenital Heart Disease

Executive Summary:Congenital heart defects (CHD) are the most common type of congenital defects in humans. It affects 1% of infants born each year. CHD can be caused by environmental exposures as well as having a genetic component to the disease. Studies have shown ~400 genes that are associated with CHD. However, 60% of the time the cause for these...
Published: 5/4/2020   |   Inventor(s): Aitor Aguirre
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical, Therapeutic

Novel Rexinoid Agonists for Kras-mediated cancer and immunotherapy

Executive Summary:KRAS is one of the most common oncogenes that, when mutated, causes normal cells to become cancerous. Current therapeutics designed to block KRAS function have not shown favorable clinical outcomes and therefore, KRAS has been deemed an “undruggable” target. However, our studies demonstrate that novel, appropriately substituted...
Published: 3/11/2020   |   Inventor(s): Karen Liby, Edmund Ellsworth, Ana Sofia Leal, Bilal Aleiwi
Keywords(s):   Category(s): Pharmaceutical, Therapeutic

Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy

Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...

Virtual Reality Training for Self-Mitigating Hand Tremors

Executive SummaryEvery individual exhibits some degree of hand tremors simply due to human physiology. While this does not typically affect daily routines even the slightest tremor is significant in fields requiring millimeter-level precision, such as eye surgery. This MSU-developed technology allows for persons to practice their hand manipulation skills...
Published: 4/12/2018   |   Inventor(s): Taiwoo Park, Cheol Song
Keywords(s):   Category(s): Medical, Therapeutic

A Smart Device-based Depression Behavior Monitoring Platform for Enhancing College Counseling Services

Executive SummaryDepression is the leading health issue on college campuses in the U.S. Today, college students are dealing with depression at some of the highest rates in decades. Unfortunately, university counseling centers (UCCs), which are the primary access points for students to receive mental health services, are facing significant challenges...
Published: 11/3/2017   |   Inventor(s): Mi Zhang, Jingbo Meng
Keywords(s):   Category(s): Computer Software, Communication, Analytical Instruments, Therapeutic

Virtual Reality-Based Training Software for Improved Recognition of Elder Abuse and Neglect

Executive SummaryElder abuse and neglect (EA/N) affects 1 in 10 older adults. Despite high prevalence rates of elder abuse and neglect (EA/N), compliance with mandatory reporting remains low; a lack of practical training on EA/N has been identified as a barrier. Researchers at Michigan State University have developed an innovative virtual-reality based...
Published: 8/10/2017   |   Inventor(s): Carolyn Ziminski Pickering
Keywords(s):   Category(s): Medical, Therapeutic

Methods and Apparatus for Determining Cuff Blood Pressure

IntroductionBlood pressure cuffs are standard equipment that can be found in hospitals, clinics and stores selling medical supplies. Patients that need to closely monitor their blood pressure may also have one at home. These cuffs employ oscillometry to measure both systolic and diastolic blood pressure by inflating the cuff to a certain pressure. Because...
Published: 11/17/2014   |   Inventor(s): Ramakrishna Mukkamala, Jiankun Liu, Jin-Oh Hahn
Keywords(s):   Category(s): Medical, Devices, Therapeutic

Methods and Apparatus for Determining Cuff-Less Blood Pressure

IntroductionBlood pressure provides health care professionals with basic, yet essential information about a patient's health and well-being. For some high risk patients, blood pressure must be consistently and in some cases constantly monitored, usually requiring an intra-arterial catheter. Traditional blood pressure cuffs are insufficient for these...
Published: 11/17/2014   |   Inventor(s): Ramakrishna Mukkamala, Mingwu Gao
Keywords(s):   Category(s): Medical, Devices, Therapeutic

Genetic Targets and Gene Therapies for Treating Levodopa-induced Dyskinesias for Parkinsonisms

IntroductionThe Parkinson’s Disease Foundation estimates that there are 1.0 to 1.5 million people suffering from Parkinson’s disease (PD) in the United States alone. Those suffering from PD are afflicted with tremors in the limbs and face, rigidity and stiffness of the limbs and trunk, slowed movement, postural instability, and impaired...
Published: 4/9/2014   |   Inventor(s): Jack Lipton, Kathy Steece-Collier, Nicholas Kanaan, Timothy Collier, Fredric Manfredsson, Caryl Sortwell
Keywords(s):   Category(s): Medical, Pharmaceutical, Therapeutic
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