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Search Results - Pharmaceutical
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Degradable Unimolecular Nanoparticles
Executive Summary Biodegradable polymers are useful as drug delivery agents. MSU researchers have developed a poly(glycolide) based polymer that forms unimolecular micelles with diameters less than 50 nm. These nanoparticles contain functional groups which provide anchoring sites for drugs, contrast agents or other biological agents. Description of...
Published: 10/26/2020
|
Inventor(s):
Gregory Baker
,
Erin Vogel
,
Milton Smith, Iii
Keywords(s):
Category(s):
Chemicals
,
Materials
,
Pharmaceutical
,
Nanotechnology
Small Molecule Inhibitors For The Treatment Of Proteinopathies
INTRODUCTIONProtein aggregation that leads to plaque formation is a contributor in many degenerative diseases including Alzheimer’s, Parkinson’s, Type 2 diabetes, and other amyloidosis diseases. Once these plaques are formed, they are extremely difficult to degrade. Breakdown and even inhibition of oligomers before formation of these plaques...
Published: 5/6/2020
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Inventor(s):
Jessica Fortin
Keywords(s):
Category(s):
Medical
,
Chemicals
,
Pharmaceutical
Evolution Of Models To Predict Protein Function Using Genetic Programming
INTRODUCTIONGenetic Programming (GP) follows the concept put forth by Darwin – “Survival of the Fittest”. Species that evolve and adapt in response to the environment are more likely to survive. GP evolves models that can optimize peptides and proteins for variety of applications. It requires only basic understanding in protein engineering....
Published: 5/6/2020
|
Inventor(s):
Assaf Gilad
,
Wolfgang Banzhaf
,
Alexander Bricco
,
Iliya Miralavykomsari
Keywords(s):
Category(s):
Biotechnology
,
Computer Software
,
Data Processing/Analysis
,
Pharmaceutical
,
Therapeutic
New Compounds to Treat, Detect and Prevent Congenital Heart Disease
Executive Summary:Congenital heart defects (CHD) are the most common type of congenital defects in humans. It affects 1% of infants born each year. CHD can be caused by environmental exposures as well as having a genetic component to the disease. Studies have shown ~400 genes that are associated with CHD. However, 60% of the time the cause for these...
Published: 5/4/2020
|
Inventor(s):
Aitor Aguirre
Keywords(s):
Category(s):
Medical
,
Biotechnology
,
Pharmaceutical
,
Therapeutic
Novel Rexinoid Agonists for Kras-mediated cancer and immunotherapy
Executive Summary:KRAS is one of the most common oncogenes that, when mutated, causes normal cells to become cancerous. Current therapeutics designed to block KRAS function have not shown favorable clinical outcomes and therefore, KRAS has been deemed an “undruggable” target. However, our studies demonstrate that novel, appropriately substituted...
Published: 3/11/2020
|
Inventor(s):
Karen Liby
,
Edmund Ellsworth
,
Ana Sofia Leal
,
Bilal Aleiwi
Keywords(s):
Category(s):
Pharmaceutical
,
Therapeutic
Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy
Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...
Published: 1/31/2020
|
Inventor(s):
Richard Lunt
,
Sophia Lunt
,
Deanna Broadwater
,
Margaret (aka Peggy) Young
,
Matthew Bates
Keywords(s):
Category(s):
Medical
,
Advanced Materials
,
Chemicals
,
Veterinary
,
Therapeutic
,
Pharmaceutical
,
Nanotechnology
Method for Improved Production of Terpenoids Using Co-Engineered Lipid Droplets and Anchoring of Terpene Biosynthetic Enzymes on Their Surface
Executive SummaryThis technology addresses one of the main hurdles of plant production and extraction of terpenoids by capturing desired terpenes in lipid droplets in plant cells. The lipid droplets are readily extracted using standard processes used in the vegetable oil and biodiesel industries, and the high-value terpenes can be easily separated...
Published: 5/28/2019
|
Inventor(s):
Björn (Bjoern) Hamberger
,
Radin Sadre
,
Christoph Benning
,
Jacob Bibik
Keywords(s):
Category(s):
Agriculture
,
Chemicals
,
Biotechnology
,
Pharmaceutical
Method for Production of Novel Diterpene Scaffolds
Executive SummaryMany insecticides currently in use are problematic due to persistence in the environment and off target effects including accumulation in apex predator species. Therefore effective crop-protecting agents that are naturally sourced and that overcome some of these side effects are under increasing demand. This technology identifies biosynthetic...
Published: 5/28/2019
|
Inventor(s):
Björn (Bjoern) Hamberger
,
Sean Johnson
,
Wajid Bhat
Keywords(s):
Category(s):
Agriculture
,
Chemicals
,
Biotechnology
,
Pharmaceutical
020009: Compositions and Methods for Epizootic Catarrhal Enteritis (ECE) Therapeutics and Diagnostics in Ferrets
In 1999, a coronavirus was identified as the cause of Epizootic Catarrhal Enteritis (ECE) in ferrets, a highly contagious diarrheal disease for which there are no effective diagnostics, therapeutics, or preventatives. This disease costs ferret breeders and owners millions of dollars a year in health care costs and lost revenue. In 1996, approximately...
Published: 11/27/2018
|
Inventor(s):
Roger Maes
,
Matti Kiupel
,
Annabel Wise
Keywords(s):
Coronavirus
,
Diagnosis
,
Ferret
,
Prevention
,
Screening
,
Treatment
,
Vaccine
Category(s):
Biotechnology
,
Pharmaceutical
,
Animal/Veterinary
Improving Pharmacokinetics and Efficacy of DFMO
Executive SummaryFor many years, the drug difluoromethylornithine (DFMO) has been shown to display chemopreventive and therapeutic properties with recent successes in the treatment of patients with high-risk neuroblastoma (NB) and colorectal cancer. In a non-cancer setting, this FDA-approved drug cures 95% of patients with West African sleeping sickness...
Published: 9/17/2018
|
Inventor(s):
Andre Bachmann
,
Thomas Dowling
Keywords(s):
Category(s):
Medical
,
Pharmaceutical
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