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Small Molecule Inhibitors For The Treatment Of Proteinopathies

INTRODUCTIONProtein aggregation that leads to plaque formation is a contributor in many degenerative diseases including Alzheimer’s, Parkinson’s, Type 2 diabetes, and other amyloidosis diseases. Once these plaques are formed, they are extremely difficult to degrade. Breakdown and even inhibition of oligomers before formation of these plaques...
Published: 5/6/2020   |   Inventor(s): Jessica Fortin
Keywords(s):   Category(s): Medical, Chemicals, Pharmaceutical

Evolution Of Models To Predict Protein Function Using Genetic Programming

INTRODUCTIONGenetic Programming (GP) follows the concept put forth by Darwin – “Survival of the Fittest”. Species that evolve and adapt in response to the environment are more likely to survive. GP evolves models that can optimize peptides and proteins for variety of applications. It requires only basic understanding in protein engineering....

New Compounds to Treat, Detect and Prevent Congenital Heart Disease

Executive Summary:Congenital heart defects (CHD) are the most common type of congenital defects in humans. It affects 1% of infants born each year. CHD can be caused by environmental exposures as well as having a genetic component to the disease. Studies have shown ~400 genes that are associated with CHD. However, 60% of the time the cause for these...
Published: 5/4/2020   |   Inventor(s): Aitor Aguirre
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical, Therapeutic

Novel Rexinoid Agonists for Kras-mediated cancer and immunotherapy

Executive Summary:KRAS is one of the most common oncogenes that, when mutated, causes normal cells to become cancerous. Current therapeutics designed to block KRAS function have not shown favorable clinical outcomes and therefore, KRAS has been deemed an “undruggable” target. However, our studies demonstrate that novel, appropriately substituted...
Published: 3/11/2020   |   Inventor(s): Karen Liby, Edmund Ellsworth, Ana Sofia Leal, Bilal Aleiwi
Keywords(s):   Category(s): Pharmaceutical, Therapeutic

Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy

Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...

Method for Improved Production of Terpenoids Using Co-Engineered Lipid Droplets and Anchoring of Terpene Biosynthetic Enzymes on Their Surface

Executive SummaryThis technology addresses one of the main hurdles of plant production and extraction of terpenoids by capturing desired terpenes in lipid droplets in plant cells. The lipid droplets are readily extracted using standard processes used in the vegetable oil and biodiesel industries, and the high-value terpenes can be easily separated...
Published: 5/28/2019   |   Inventor(s): Bjoern Hamberger, Radin Sadre, Christoph Benning, Jacob Bibik
Keywords(s):   Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical

Method for Production of Novel Diterpene Scaffolds

Executive SummaryMany insecticides currently in use are problematic due to persistence in the environment and off target effects including accumulation in apex predator species. Therefore effective crop-protecting agents that are naturally sourced and that overcome some of these side effects are under increasing demand. This technology identifies biosynthetic...
Published: 5/28/2019   |   Inventor(s): Bjoern Hamberger, Sean Johnson, Wajid Bhat
Keywords(s):   Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical

020009: Compositions and Methods for Epizootic Catarrhal Enteritis (ECE) Therapeutics and Diagnostics in Ferrets

In 1999, a coronavirus was identified as the cause of Epizootic Catarrhal Enteritis (ECE) in ferrets, a highly contagious diarrheal disease for which there are no effective diagnostics, therapeutics, or preventatives. This disease costs ferret breeders and owners millions of dollars a year in health care costs and lost revenue. In 1996, approximately...
Published: 11/27/2018   |   Inventor(s): Roger Maes, Matti Kiupel, Annabel Wise
Keywords(s): Coronavirus, Diagnosis, Ferret, Prevention, Screening, Treatment, Vaccine Category(s): Biotechnology, Pharmaceutical, Animal/Veterinary

Improving Pharmacokinetics and Efficacy of DFMO

Executive SummaryFor many years, the drug difluoromethylornithine (DFMO) has been shown to display chemopreventive and therapeutic properties with recent successes in the treatment of patients with high-risk neuroblastoma (NB) and colorectal cancer. In a non-cancer setting, this FDA-approved drug cures 95% of patients with West African sleeping sickness...
Published: 9/17/2018   |   Inventor(s): Andre Bachmann, Thomas Dowling
Keywords(s):   Category(s): Medical, Pharmaceutical

Novel MmpL3 Inhibitor as a Treatment of Mycobacterium Tuberculosis

Executive SummaryMycobacterium Tuberculosis (Mtb) is the pathogen responsible for Tuberculosis. Standard TB treatments typically require four different drugs and a duration of six to nine months of treatment; however, there is still an evolution of drug-resistant Mtb. With not only Tuberculosis, but drug-resistant Tuberculosis causing upwards of 1.5...
Published: 6/4/2018   |   Inventor(s): Robert Abramovitch, Huiqing Zheng
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical
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