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Extracellular Vesicle Library for Drug Screening

­ Executive Summary The body’s natural transporter, Extracellular vesicles (EVs), have gained recent attention for their potential as targeted drug delivery vehicles with low immunogenic response. Properly designing the surface allows EVs to deliver therapeutic payloads (protein, RNA, nanoparticle, small molecule, etc.) to a target organ....
Published: 3/11/2023   |   Inventor(s): Chris Contag, Masako Harada
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Hybrid Gelatin Methacryloyl-Silver Bioactive Glass Bioink

­Executive Summary Three dimensional (3D) bioprinting is an emerging field that involves producing tissue structures with 3D printing techniques. Examples include bone tissue/fillers, synthetic skin, scaffolds for drug delivery and tissues for dental repair. Common 3D bioprinting methods include extrusion, stereolithography and microfluidics-based...
Published: 2/17/2023   |   Inventor(s): Nureddin Shammakhi, Xanthippi Chatzistavrou
Keywords(s):   Category(s): Medical, Advanced Materials, Nanotechnology, Pharmaceutical

Microfluidic Apparatus For Respirometry

Executive Summary Cellular respiration is a set of metabolic processes responsible for the conversion of chemical energy in all aerobic organisms. In animal and plant cells this takes place in the mitochondria where food is broken down to CO2 and strongly reducing compounds. Energy released upon oxidation of the latter by molecular oxygen via a chain...
Published: 2/17/2023   |   Inventor(s): Denis Proshlyakov, Julia Busik
Keywords(s):   Category(s): Medical, Devices, Pharmaceutical, Test and Measurement, Biotechnology

Antibacterial Silicate Glass-Ceramic Filament for 3D Printing Bone Materials

INTRODUCTION The use of 3D printed porous scaffolds provides a multi-dimensional template that closely mimics the native structure of bone. This is beneficial for creating ideal conditions for bone tissue regeneration. Silicate bioactive glass-ceramics are inherently bioconductive and bioinductive, making them ideal for tissue regeneration. DESCRIPTION...
Published: 8/20/2022   |   Inventor(s): Aljoscha Roch, Xanthippi Chatzistavrou
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Therapeutic for Tissue Healing and Resistive Bacteria

INTRODUCTION Healing infected tissue and combating resistant bacteria are significant clinical challenges. Antibiotic-based therapies are increasingly unsuccessful due to the ability of pathogens to develop resistance. Methicillin resistant Staphylococcus aureus (MRSA), for example, is a leading cause of many infections, including skin and soft tissue...
Published: 2/17/2023   |   Inventor(s): Xanthippi Chatzistavrou, Neal Hammer
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Degradable Unimolecular Nanoparticles

Executive Summary Biodegradable polymers are useful as drug delivery agents. MSU researchers have developed a poly(glycolide) based polymer that forms unimolecular micelles with diameters less than 50 nm. These nanoparticles contain functional groups which provide anchoring sites for drugs, contrast agents or other biological agents. Description of...
Published: 6/8/2021   |   Inventor(s): Gregory Baker, Erin Vogel, Milton Smith, Iii
Keywords(s):   Category(s): Chemicals, Materials, Pharmaceutical, Nanotechnology

Small Molecule Inhibitors For The Treatment Of Proteinopathies

INTRODUCTIONProtein aggregation that leads to plaque formation is a contributor in many degenerative diseases including Alzheimer’s, Parkinson’s, Type 2 diabetes, and other amyloidosis diseases. Once these plaques are formed, they are extremely difficult to degrade. Breakdown and even inhibition of oligomers before formation of these plaques...
Published: 3/21/2023   |   Inventor(s): Jessica Fortin
Keywords(s):   Category(s): Medical, Chemicals, Pharmaceutical

Evolution Of Models To Predict Protein Function Using Genetic Programming

INTRODUCTIONGenetic Programming (GP) follows the concept put forth by Darwin – “Survival of the Fittest”. Species that evolve and adapt in response to the environment are more likely to survive. GP evolves models that can optimize peptides and proteins for variety of applications. It requires only basic understanding in protein engineering....
Published: 2/17/2023   |   Inventor(s): Assaf Gilad, Wolfgang Banzhaf, Alexander Bricco, Iliya Miralavykomsari
Keywords(s):   Category(s): Biotechnology, Computer Software, Data Processing/Analysis, Pharmaceutical, Therapeutic

Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy

Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...
Published: 2/17/2023   |   Inventor(s): Richard Lunt, III, Sophia Lunt, Deanna Broadwater, Margaret (aka Peggy) Young, Matthew Bates
Keywords(s):   Category(s): Medical, Advanced Materials, Chemicals, Veterinary, Therapeutic, Pharmaceutical, Nanotechnology

Method for Improved Production of Terpenoids Using Co-Engineered Lipid Droplets and Anchoring of Terpene Biosynthetic Enzymes on Their Surface

Executive SummaryThis technology addresses one of the main hurdles of plant production and extraction of terpenoids by capturing desired terpenes in lipid droplets in plant cells. The lipid droplets are readily extracted using standard processes used in the vegetable oil and biodiesel industries, and the high-value terpenes can be easily separated...
Published: 2/17/2023   |   Inventor(s): Björn (Bjoern) Hamberger, Radin Sadre, Christoph Benning, Jacob Bibik
Keywords(s):   Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical
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