Search Results - Pharmaceutical

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Treatment for Neuroblastoma and other Polyamine-dependent Diseases with New DFMO and Adjuvant Drug Combination

Executive SummaryFor many years, the drug difluoromethylornithine (DFMO) has been shown to display chemopreventive and therapeutic properties with recent successes in the treatment of patients with high-risk neuroblastoma (NB) and colorectal cancer. In a non-cancer setting, this FDA-approved drug cures 95% of patients with West African sleeping sic...
Published: 9/17/2018   |   Inventor(s): Andre Bachmann, Thomas Dowling
Keywords(s):   Category(s): Medical, Pharmaceutical

Novel MmpL3 Inhibitor as a Treatment of Mycobacterium Tuberculosis

Executive SummaryMycobacterium Tuberculosis (Mtb) is the pathogen responsible for Tuberculosis. Standard TB treatments typically require four different drugs and a duration of six to nine months of treatment; however, there is still an evolution of drug-resistant Mtb. With not only Tuberculosis, but drug-resistant Tuberculosis causing upwards of 1....
Published: 6/4/2018   |   Inventor(s): Robert Abramovitch, Huiqing Zheng
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Improved Technology for Mannitol Production

Executive SummaryIndustrialized production of mannitol for use as a food sweetener and various pharmaceutical applications is currently achieved by hydrogenation of a fructose/glucose syrup at high pressures and temperatures. The reaction produces a mixture of mannitol and sorbitol that is both inefficient (70% sorbitol as end-product) and requires...
Published: 5/31/2018   |   Inventor(s): Claire Vieille, Seung Hoon Song, J. Gregory Zeikus
Keywords(s):   Category(s): Chemicals, Biotechnology, Pharmaceutical

Novel Chemical Inhibitors of Mycobacterium Tuberculosis Targeting the DosRST Pathway – Tuberculosis Treatment

Executive SummaryTuberculosis (TB) is a potentially fatal infectious disease caused by the bacterium, Mycobacterium tuberculosis (Mtb). According to the Centers for Disease Control and Prevention (CDC), TB is one of the world’s deadliest diseases and responsible for upwards of 1.5 million deaths annually. TB is also a leading killer of HIV-in...
Published: 5/24/2018   |   Inventor(s): Robert Abramovitch, Edmund Ellsworth
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Mobile Phone App for Real Time Pill Recognition

Executive SummaryThe ability to quickly and reliably be able to identify both prescription and non-prescription medications is not only important for a patient and his caretaker, but also important for pharmacists, nurses, and law enforcement agents. Despite unique FDA-approved identifiers for each pill, distinguishing the differences can be diffic...
Published: 4/18/2018   |   Inventor(s): Mi Zhang, Kai Cao, Xiao Zeng
Keywords(s):   Category(s): Medical, Computer Software, Pharmaceutical

Novel Compounds to Treat Canine Histiocytic Sarcomas and Other Malignancies

Executive SummaryHistiocytic sarcomas are very aggressive and invasive tumors that occur with high incidence in Bernese Mountain dogs, Rottweilers, Flat Coated Retrievers, and Golden Retrievers. The prognosis of histiocytic sarcomas is poor with median survival time of a few weeks to a few months. The currently available clinical treatments, includ...
Published: 8/10/2017   |   Inventor(s): Vilma Yuzbasiyan-Gurkan, Jetze Tepe
Keywords(s):   Category(s): Medical, Animal/Veterinary, Pharmaceutical

Chemical Treatment for Osteoporosis

Executive SummaryCurrently available therapeutics for osteoporosis have the potential to produce severe negative side effects or are required to be administered via injection. Researchers at Michigan State University have developed a new therapeutic that overcomes these challenges.Description of TechnologyThis novel MSU technology uses high molecul...
Published: 6/28/2017   |   Inventor(s): Laura Mccabe, Rifat Pamukcu
Keywords(s):   Category(s): Biotechnology, Pharmaceutical

Cyclic Peptide Production Enzymes and System

Executive SummaryCyclic peptides tend to be resistant to peptidases and therefore stable in vivo. Their size, chemical properties, and ability to interact with biomolecules suggest that they make good pharmaceutical and agricultural active ingredient candidates. However, intra-molecular cyclization is difficult and competes with unwanted inter-mol...
Published: 6/14/2017   |   Inventor(s): Jonathan Walton, Heather Hallen-Adams, John Scott-Craig, Hong Luo
Keywords(s):   Category(s): Biotechnology, Chemicals, Pharmaceutical

Inhibition of the Mycobacterium Tuberculosis Virulence Using Ethoxzolamide

Executive SummaryTo address the pitfalls of traditional antibiotic tuberculosis therapies, such as the emergence of multi-drug resistant bacterial strains, alternative treatment strategies are currently being pursued. Researchers at Michigan State University (MSU) have developed a promising anti-virulence treatment strategy for Mycobacterium tuberc...
Published: 12/28/2016   |   Inventor(s): Robert Abramovitch, Benjamin Johnson, Christopher Colvin
Keywords(s):   Category(s): Medical, Pharmaceutical

Biocatalysis of Bioactive Taxanes

Executive SummaryA shortage of the chemotherapeutic paclitaxel (Taxol®) due to an unreliable pharmaceutical supply chain lead researchers at Michigan State University (MSU) to discover and propose a novel, faster way of producing paclitaxel and related anti-cancer drugs: Using a biocatalytic process, Taxol can now be produced in a more streamli...
Published: 12/28/2016   |   Inventor(s): Kevin Walker
Keywords(s):   Category(s): Medical, Pharmaceutical
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