Search Results - Pharmaceutical

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Novel Compounds to Treat Canine Histiocytic Sarcomas and Other Malignancies

Executive SummaryHistiocytic sarcomas are very aggressive and invasive tumors that occur with high incidence in Bernese Mountain dogs, Rottweilers, Flat Coated Retrievers, and Golden Retrievers. The prognosis of histiocytic sarcomas is poor with median survival time of a few weeks to a few months. The currently available clinical treatments, includ...
Published: 8/10/2017   |   Inventor(s): Vilma Yuzbasiyan-Gurkan, Jetze Tepe
Keywords(s):   Category(s): Medical, Animal/Veterinary, Pharmaceutical

Chemical Treatment for Osteoporosis

Executive SummaryCurrently available therapeutics for osteoporosis have the potential to produce severe negative side effects or are required to be administered via injection. Researchers at Michigan State University have developed a new therapeutic that overcomes these challenges.Description of TechnologyThis novel MSU technology uses high molecul...
Published: 6/28/2017   |   Inventor(s): Laura McCabe, Rifat Pamukcu
Keywords(s):   Category(s): Biotechnology, Pharmaceutical

Cyclic Peptide Production Enzymes and System

Executive SummaryCyclic peptides tend to be resistant to peptidases and therefore stable in vivo. Their size, chemical properties, and ability to interact with biomolecules suggest that they make good pharmaceutical and agricultural active ingredient candidates. However, intra-molecular cyclization is difficult and competes with unwanted inter-mol...
Published: 6/14/2017   |   Inventor(s): Jonathan Walton, Heather Hallen-Adams, John Scott-Craig, Hong Luo
Keywords(s):   Category(s): Biotechnology, Chemicals, Pharmaceutical

Inhibition of the Mycobacterium Tuberculosis Virulence Using Ethoxzolamide

Executive SummaryTo address the pitfalls of traditional antibiotic tuberculosis therapies, such as the emergence of multi-drug resistant bacterial strains, alternative treatment strategies are currently being pursued. Researchers at Michigan State University (MSU) have developed a promising anti-virulence treatment strategy for Mycobacterium tuberc...
Published: 12/28/2016   |   Inventor(s): Robert Abramovitch, Benjamin Johnson, Christopher Colvin
Keywords(s):   Category(s): Medical, Pharmaceutical

Biocatalysis of Bioactive Taxanes

Executive SummaryA shortage of the chemotherapeutic paclitaxel (Taxol®) due to an unreliable pharmaceutical supply chain lead researchers at Michigan State University (MSU) to discover and propose a novel, faster way of producing paclitaxel and related anti-cancer drugs: Using a biocatalytic process, Taxol can now be produced in a more streamli...
Published: 12/28/2016   |   Inventor(s): Kevin Walker
Keywords(s):   Category(s): Medical, Pharmaceutical

Direct Thrombin Inhibitors for Diet-Induced Obesity and Fatty Liver Disease

Executive SummaryNon-alcoholic fatty liver disease (NALFD) affects approximately 20% of US adults and nearly 75% of obese adults. As NALFD becomes more severe, non-alcoholic steatohepatitis (NASH) develops, which can lead to liver failure. The only ways to treat these diseases are through weight loss, or in extreme cases, liver transplants. Researc...
Published: 12/12/2016   |   Inventor(s): James Luyendyk
Keywords(s):   Category(s): Medical, Pharmaceutical

Chemical Compounds that Limit Mycobacterium Tuberculosis Growth in Vitro or in Vivo

Executive SummaryMycobacterium tuberculosis (M. tuberculosis) causes the disease tuberculosis (TB) in humans. Driven by the hypoxic environment of the granuloma, M. tuberculosis enters a persistent, non-replicating state that is recalcitrant to antibiotic therapy. Treatment requires a multidrug, 6-9 month therapeutic regimen which has fueled the ...
Published: 10/14/2016   |   Inventor(s): Robert Abramovitch, Christopher Colvin, Benjamin Johnson
Keywords(s):   Category(s): Pharmaceutical, Medical

Targeting a Kinase Pathway to Treat Cancer

Executive SummaryThere is a tremendous need for effective, nontoxic therapies to treat patients with glioblastoma, the most common and lethal malignant primary brain tumors. With current therapies (e.g. temozolomide and bevacizumab) life expectancy is about 15 months. MSU research results indicate that the proliferation and invasion of glioblasto...
Published: 10/14/2016   |   Inventor(s): Kathleen Gallo
Keywords(s):   Category(s): Pharmaceutical, Medical

Identifying and Monitoring Neurological Diseases through Speech

Executive SummaryEarly detection of neurodegenerative diseases such as Parkinson’s disease is critical to a successful treatment and management of the condition. Scientists at Michigan State University, University of Florida and University of Georgia have devised a way to identify whether patients suffer from Parkinson’s disease and to ...
Published: 7/6/2016   |   Inventor(s): Rahul Shrivastav, Mark Skowronski, Supraja Anand, John Rosenbek
Keywords(s):   Category(s): Medical, Pharmaceutical

Novel Regulator of Algal Lipid Metabolism and Cellular Quiescence and Its Applications

IntroductionAlgae typically accumulate valuable compounds under conditions that are unfavorable to growth. For example nutrient starvation causes accumulation of triacylglycerols (oil), but also induces cellular quiescence, a “pause” stage where algae stop growing and reproducing. This leads to a problematic inverse relationship betwee...
Published: 9/25/2015   |   Inventor(s): Christoph Benning, Chia-Hong Tsai
Keywords(s):   Category(s): Agriculture, Biotechnology, Pharmaceutical, Energy
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