MSU Technologies

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Microfluidic Apparatus For Respirometry

Executive Summary Cellular respiration is a set of metabolic processes responsible for the conversion of chemical energy in all aerobic organisms. In animal and plant cells this takes place in the mitochondria where food is broken down to CO2 and strongly reducing compounds. Energy released upon oxidation of the latter by molecular oxygen via a chain...

Published: 10/20/2021 | Inventor(s): Denis Proshlyakov, Julia Busik

Keywords(s): Category(s): Medical, Devices, Pharmaceutical, Test and Measurement, Biotechnology

Antibacterial Silicate Glass-Ceramic Filament for 3D Printing Bone Materials

INTRODUCTION The use of 3D printed porous scaffolds provides a multi-dimensional template that closely mimics the native structure of bone. This is beneficial for creating ideal conditions for bone tissue regeneration. Silicate bioactive glass-ceramics are inherently bioconductive and bioinductive, making them ideal for tissue regeneration. DESCRIPTION...

Published: 6/14/2021 | Inventor(s): Aljoscha Roch NO LONGER AT MSU, Xanthippi Chatzistavrou

Keywords(s): Category(s): Medical, Biotechnology, Pharmaceutical

Therapeutic for Tissue Healing and Resistive Bacteria

INTRODUCTION Healing infected tissue and combating resistant bacteria are significant clinical challenges. Antibiotic-based therapies are increasingly unsuccessful due to the ability of pathogens to develop resistance. Methicillin resistant Staphylococcus aureus (MRSA), for example, is a leading cause of many infections, including skin and soft tissue...

Published: 6/14/2021 | Inventor(s): Xanthippi Chatzistavrou, Neal Hammer

Keywords(s): Category(s): Medical, Biotechnology, Pharmaceutical

Degradable Unimolecular Nanoparticles

Executive Summary Biodegradable polymers are useful as drug delivery agents. MSU researchers have developed a poly(glycolide) based polymer that forms unimolecular micelles with diameters less than 50 nm. These nanoparticles contain functional groups which provide anchoring sites for drugs, contrast agents or other biological agents. Description of...

Published: 10/26/2020 | Inventor(s): Gregory Baker, Erin Vogel, Milton Smith, Iii

Keywords(s): Category(s): Chemicals, Materials, Pharmaceutical, Nanotechnology

Small Molecule Inhibitors For The Treatment Of Proteinopathies

INTRODUCTIONProtein aggregation that leads to plaque formation is a contributor in many degenerative diseases including Alzheimer’s, Parkinson’s, Type 2 diabetes, and other amyloidosis diseases. Once these plaques are formed, they are extremely difficult to degrade. Breakdown and even inhibition of oligomers before formation of these plaques...

Published: 5/6/2020 | Inventor(s): Jessica Fortin

Keywords(s): Category(s): Medical, Chemicals, Pharmaceutical

Evolution Of Models To Predict Protein Function Using Genetic Programming

INTRODUCTIONGenetic Programming (GP) follows the concept put forth by Darwin – “Survival of the Fittest”. Species that evolve and adapt in response to the environment are more likely to survive. GP evolves models that can optimize peptides and proteins for variety of applications. It requires only basic understanding in protein engineering....

Published: 5/6/2020 | Inventor(s): Assaf Gilad, Wolfgang Banzhaf, Alexander Bricco, Iliya Miralavykomsari

Keywords(s): Category(s): Biotechnology, Computer Software, Data Processing/Analysis, Pharmaceutical, Therapeutic

Novel Rexinoid Agonists for Kras-mediated cancer and immunotherapy

Executive Summary:KRAS is one of the most common oncogenes that, when mutated, causes normal cells to become cancerous. Current therapeutics designed to block KRAS function have not shown favorable clinical outcomes and therefore, KRAS has been deemed an “undruggable” target. However, our studies demonstrate that novel, appropriately substituted...

Published: 3/11/2020 | Inventor(s): Karen Liby, Edmund Ellsworth, Ana Sofia Leal, Bilal Aleiwi

Keywords(s): Category(s): Pharmaceutical, Therapeutic

Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy

Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...

Published: 1/31/2020 | Inventor(s): Richard Lunt, Sophia Lunt, Deanna Broadwater, Margaret (aka Peggy) Young, Matthew Bates

Keywords(s): Category(s): Medical, Advanced Materials, Chemicals, Veterinary, Therapeutic, Pharmaceutical, Nanotechnology

Method for Improved Production of Terpenoids Using Co-Engineered Lipid Droplets and Anchoring of Terpene Biosynthetic Enzymes on Their Surface

Executive SummaryThis technology addresses one of the main hurdles of plant production and extraction of terpenoids by capturing desired terpenes in lipid droplets in plant cells. The lipid droplets are readily extracted using standard processes used in the vegetable oil and biodiesel industries, and the high-value terpenes can be easily separated...

Published: 5/28/2019 | Inventor(s): Björn (Bjoern) Hamberger, Radin Sadre, Christoph Benning, Jacob Bibik

Keywords(s): Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical

Method for Production of Novel Diterpene Scaffolds

Executive SummaryMany insecticides currently in use are problematic due to persistence in the environment and off target effects including accumulation in apex predator species. Therefore effective crop-protecting agents that are naturally sourced and that overcome some of these side effects are under increasing demand. This technology identifies biosynthetic...

Published: 5/28/2019 | Inventor(s): Björn (Bjoern) Hamberger, Sean Johnson, Wajid Bhat