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A Method for Predicting Therapeutic Response in Parkinson’s Disease

Executive SummaryMSU and Vanderbilt researchers have found a method for predicting therapeutic response in Parkinson’s disease. The leading treatments, levodopa and deep brain stimulation, are generally effective in treating the motor symptoms of Parkinson’s disease, but the clinical response is highly variable depending on the disease’s...
Published: 2/17/2023   |   Inventor(s): Caryl Sortwell, Jack Lipton, David Charles, Mallory Hacker
Keywords(s):   Category(s): Medical

Nurr1 as a Genetic Target for Treating Levodopa-induced Dyskinesias (LIDs) in Parkinson's Disease

Executive SummaryPatients afflicted with Parkinson’s disease often develop severely debilitating movement disorders as side effects from currently available treatment options. Researchers at MSU propose to use a new gene therapy approach that will both reduce these side effects and prolong the effectiveness of treatment by targeted gene silencing.Description...
Published: 8/20/2022   |   Inventor(s): Fredric Manfredsson, Kathy Steece-Collier, Jack Lipton, Timothy Collier, Nicholas Kanaan, Caryl Sortwell
Keywords(s):   Category(s): Medical

Use of Sprr1 A-like Protein as a Neurorestorative and Neuroprotective Agent against Neurodegeneration in Parkinson's Disease

Executive SummaryAlthough the precise causes of Parkinson’s disease (PD) remain unclear, it has been long observed that those afflicted with the disease show widespread neurodegeneration of the central nervous system accompanied by a striking loss of dopamine producing neurons in the brain. Recent research suggests axonal degeneration of dopamine...
Published: 2/8/2024   |   Inventor(s): Nicholas Kanaan, Jack Lipton, Timothy Collier
Keywords(s):   Category(s): Medical