Search Results - fredric manfredsson

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Novel Gene Therapies to Mitigate Neurotoxicity for Improved Treatment of Neurodegenerative Disease

Executive SummaryDysfunction of the kynurenine pathway has been linked to Parkinson’s disease, Alzheimer’s disease, ALS, Huntington’s disease, brain ischemia, CNS infections, autoimmune disorders, mood disorders, and schizophrenia. If this pathway could be manipulated neuroprotection could be achieved. Description of TechnologyMSU...
Published: 3/10/2017   |   Inventor(s): Fredric Manfredsson, Lena Brundin
Keywords(s):   Category(s): Medical, Biotechnology

Recombinant Adeno-Associated Virus Capsid Mutants for Enhanced Transduction of Therapeutic Genetic Material in the CNS

Executive SummaryThe largest limiting factor in viral-mediated gene therapy is the efficacy of gene delivery to the target cells, which is dependent on the level of transduction. This becomes particularly important for therapies directly injected into the brain or central nervous system (CNS) as only a limited volume can be injected and the procedure...
Published: 12/12/2016   |   Inventor(s): Fredric Manfredsson, Nicholas Kanaan
Keywords(s):   Category(s): Medical

High Throughput Production of Recombinant Adeno-Associated Virus Libraries

Executive SummaryEach year the number of published genomes increases, challenging scientists to identify the purpose of thousands of new genes of unknown function. Analysis of such a large volume of data calls for high throughput screening of genetic material, which plays a key role in modern drug discovery. The use of viral vectors to perform high...
Published: 10/14/2016   |   Inventor(s): Fredric Manfredsson
Keywords(s):   Category(s): Biotechnology

Nurr1 as a Genetic Target for Treating Levodopa-induced Dyskinesias (LIDs) in Parkinson's Disease

Executive SummaryPatients afflicted with Parkinson’s disease often develop severely debilitating movement disorders as side effects from currently available treatment options. Researchers at MSU propose to use a new gene therapy approach that will both reduce these side effects and prolong the effectiveness of treatment by targeted gene silencing.Description...
Published: 6/23/2016   |   Inventor(s): Fredric Manfredsson, Kathy Steece-Collier, Jack Lipton, Timothy Collier, Nicholas Kanaan, Caryl Sortwell
Keywords(s):   Category(s): Medical

Genetic Targets and Gene Therapies for Treating Levodopa-induced Dyskinesias for Parkinsonisms

IntroductionThe Parkinson’s Disease Foundation estimates that there are 1.0 to 1.5 million people suffering from Parkinson’s disease (PD) in the United States alone. Those suffering from PD are afflicted with tremors in the limbs and face, rigidity and stiffness of the limbs and trunk, slowed movement, postural instability, and impaired...
Published: 4/9/2014   |   Inventor(s): Jack Lipton, Kathy Steece-Collier, Nicholas Kanaan, Timothy Collier, Fredric Manfredsson, Caryl Sortwell
Keywords(s):   Category(s): Medical, Pharmaceutical, Therapeutic