Search Results - caryl sortwell

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A Method for Predicting Therapeutic Response in Parkinson’s Disease

Executive SummaryMSU and Vanderbilt researchers have found a method for predicting therapeutic response in Parkinson’s disease. The leading treatments, levodopa and deep brain stimulation, are generally effective in treating the motor symptoms of Parkinson’s disease, but the clinical response is highly variable depending on the disease’s...
Published: 6/23/2016   |   Inventor(s): Caryl Sortwell, Jack Lipton, David Charles, Mallory Hacker
Keywords(s):   Category(s): Medical

Nurr1 as a Genetic Target for Treating Levodopa-induced Dyskinesias (LIDs) in Parkinson's Disease

Executive SummaryPatients afflicted with Parkinson’s disease often develop severely debilitating movement disorders as side effects from currently available treatment options. Researchers at MSU propose to use a new gene therapy approach that will both reduce these side effects and prolong the effectiveness of treatment by targeted gene silencing.Description...
Published: 6/23/2016   |   Inventor(s): Fredric Manfredsson, Kathy Steece-Collier, Jack Lipton, Timothy Collier, Nicholas Kanaan, Caryl Sortwell
Keywords(s):   Category(s): Medical

Genetic Targets and Gene Therapies for Treating Levodopa-induced Dyskinesias for Parkinsonisms

IntroductionThe Parkinson’s Disease Foundation estimates that there are 1.0 to 1.5 million people suffering from Parkinson’s disease (PD) in the United States alone. Those suffering from PD are afflicted with tremors in the limbs and face, rigidity and stiffness of the limbs and trunk, slowed movement, postural instability, and impaired...
Published: 4/9/2014   |   Inventor(s): Jack Lipton, Kathy Steece-Collier, Nicholas Kanaan, Timothy Collier, Fredric Manfredsson, Caryl Sortwell
Keywords(s):   Category(s): Medical, Pharmaceutical, Therapeutic