Search Results - edmund ellsworth

3 Results Sort By:

Novel Rexinoid Agonists for Kras-mediated cancer and immunotherapy

Executive Summary:KRAS is one of the most common oncogenes that, when mutated, causes normal cells to become cancerous. Current therapeutics designed to block KRAS function have not shown favorable clinical outcomes and therefore, KRAS has been deemed an “undruggable” target. However, our studies demonstrate that novel, appropriately substituted...
Published: 3/11/2020   |   Inventor(s): Karen Liby, Edmund Ellsworth, Ana Sofia Leal, Bilal Aleiwi
Keywords(s):   Category(s): Pharmaceutical, Therapeutic

Biosynthesis of Chemically Diversified Non-Natural Terpene Products

Executive SummaryDrug and chemical discovery is a lengthy, difficult, and inefficient process. The production of new drugs and chemicals is bottlenecked at synthesis or biosynthesis of complicated molecules, especially chiral molecules. Furthermore, diversification of current drug and chemical libraries is hindered by these difficult and inefficient...
Published: 1/8/2020   |   Inventor(s): Edmund Ellsworth, Matthew Giletto, Bjoern Hamberger, Garret Miller, Richard Neubig
Keywords(s):   Category(s): Biotechnology, Chemicals

Novel Chemical Inhibitors of Mycobacterium Tuberculosis Targeting the DosRST Pathway – Tuberculosis Treatment

Executive SummaryTuberculosis (TB) is a potentially fatal infectious disease caused by the bacterium, Mycobacterium tuberculosis (Mtb). According to the Centers for Disease Control and Prevention (CDC), TB is one of the world’s deadliest diseases and responsible for upwards of 1.5 million deaths annually. TB is also a leading killer of HIV-infected...
Published: 5/24/2018   |   Inventor(s): Robert Abramovitch, Edmund Ellsworth
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical