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Treatment for Neuroblastoma and other Polyamine-dependent Diseases with New DFMO and Adjuvant Drug Combination

Executive SummaryFor many years, the drug difluoromethylornithine (DFMO) has been shown to display chemopreventive and therapeutic properties with recent successes in the treatment of patients with high-risk neuroblastoma (NB) and colorectal cancer. In a non-cancer setting, this FDA-approved drug cures 95% of patients with West African sleeping sic...
Published: 9/17/2018   |   Inventor(s): Andre Bachmann, Thomas Dowling
Keywords(s):   Category(s): Medical, Pharmaceutical

System for Identifying Brain Functional Area

Executive SummaryMagnetic Resonance Imaging, or MRI, has revolutionized non-invasive diagnostic methods used in modern medicine. Furthermore, functional MRI (fMRI) has allowed researchers and technicians to observe neuron activity directly by monitoring blood oxygen levels within small areas of the brain. However, steady states of activity must be ...
Published: 9/13/2018   |   Inventor(s): Jie Huang
Keywords(s):   Category(s): Medical, Biotechnology, Computer Software, Data Processing/Analysis

Prediction of Abdominal Aortic Aneurysm Expansion using Bayesian Calibration

Executive SummaryEnsuring that surgeries for Abdominal Aortic Aneurysms (AAA) are performed at the appropriate time is important to reduce the high mortality rates associated with this serious disease. During the past decade, a computational platform called a Growth & Remodeling (G&R) model has been developed to aid in this process. MSU r...
Published: 8/30/2018   |   Inventor(s): Seungik Baek, Tapabrata Maiti, Chae Young Lim, Jongeun Choi, Liangliang Zhang, Justin Mrkva
Keywords(s):   Category(s): Medical, Computer Software, Data Processing/Analysis

Virus-Like Particle for Vaccine Development

Executive SummaryWith the increasing attention on safety, vaccine development is more focused on targeting subunit epitopes. Thus, a suitable carrier that is capable of powerfully activate the immune system and elicit desired immune responses is critical. MSU researchers have developed new virus like particle (VLP) based platform technology, which ...
Published: 6/15/2018   |   Inventor(s): Xuefei Huang, Suttipun Sungsuwan
Keywords(s):   Category(s): Medical

Novel MmpL3 Inhibitor as a Treatment of Mycobacterium Tuberculosis

Executive SummaryMycobacterium Tuberculosis (Mtb) is the pathogen responsible for Tuberculosis. Standard TB treatments typically require four different drugs and a duration of six to nine months of treatment; however, there is still an evolution of drug-resistant Mtb. With not only Tuberculosis, but drug-resistant Tuberculosis causing upwards of 1....
Published: 6/4/2018   |   Inventor(s): Robert Abramovitch, Huiqing Zheng
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Novel Chemical Inhibitors of Mycobacterium Tuberculosis Targeting the DosRST Pathway – Tuberculosis Treatment

Executive SummaryTuberculosis (TB) is a potentially fatal infectious disease caused by the bacterium, Mycobacterium tuberculosis (Mtb). According to the Centers for Disease Control and Prevention (CDC), TB is one of the world’s deadliest diseases and responsible for upwards of 1.5 million deaths annually. TB is also a leading killer of HIV-in...
Published: 5/24/2018   |   Inventor(s): Robert Abramovitch, Edmund Ellsworth
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Mobile Phone App for Real Time Pill Recognition

Executive SummaryThe ability to quickly and reliably be able to identify both prescription and non-prescription medications is not only important for a patient and his caretaker, but also important for pharmacists, nurses, and law enforcement agents. Despite unique FDA-approved identifiers for each pill, distinguishing the differences can be diffic...
Published: 4/18/2018   |   Inventor(s): Mi Zhang, Kai Cao, Xiao Zeng
Keywords(s):   Category(s): Medical, Computer Software, Pharmaceutical

Improved Ex Vivo Hematopoietic Stem Cell Culture System

Executive SummaryHematopoietic stem cell (HSC) transplants are widely used to restore a patients’ bone marrow or immune system suffered damaged due to radiation or chemotherapy. The regenerative capability of HSC therapy has been limited as only a few cells can be isolated and these cells do not expand in culture. Michigan State University ha...
Published: 4/18/2018   |   Inventor(s): Peter Lillehoj, Gorachand Dutta
Keywords(s):   Category(s): Medical

Virtual Reality Training for Self-Mitigating Hand Tremors

Executive SummaryEvery individual exhibits some degree of hand tremors simply due to human physiology. While this does not typically affect daily routines even the slightest tremor is significant in fields requiring millimeter-level precision, such as eye surgery. This MSU-developed technology allows for persons to practice their hand manipulation ...
Published: 4/12/2018   |   Inventor(s): Taiwoo Park, Cheol Song
Keywords(s):   Category(s): Medical, Therapeutic

Surgical Device to Measure the Softness/Hardness of the Pancreas

Executive SummaryA common problem for pancreatic surgeons is the prevention of pancreatic leaks in the post-operation phase of pancreatic surgery. Pancreatic leaks can cause serious health problems for the patients and are sometimes fatal. Researchers at MSU are addressing this problem using the state of the art technology and engineering.Descripti...
Published: 1/24/2018   |   Inventor(s): Srinivas Kavuturu, Ranjan Mukherjee
Keywords(s):   Category(s): Medical, Veterinary
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