Search Results - Biotechnology

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Adsorbed Polymer Coatings to Create Protein- and metal-Adsorbing Membranes

Executive SummaryTo rapidly purify proteins, one might derivatize membranes through growth of polymer brushes, however direct polymer adsorption is much simpler and essentially as effective. In this invention, MSU researchers deposit polymers that already contain metal-binding ligands, which greatly simplifies the procedure and reduces the waste of...
Published: 12/4/2017   |   Inventor(s): Merlin Bruening, Salinda Wijeratne, Wenjing Ning, Jinlan Dong, Weijing Liu
Keywords(s):   Category(s): Biotechnology

CH12F3 Cell Line with Various Knock-Outs

Executive SummaryThe CH12F3 mouse B lymphocyte cell lines are useful tools to study the role of DNA metabolism in modulating immunoglobulin genes and DNA repair. Since enzymes involved in DNA metabolism play essential roles in embryogenesis, knockout of these proteins often resulted in lethality in mouse embryonic stem cells. MSU researchers have d...
Published: 12/4/2017   |   Inventor(s): Kefei Yu
Keywords(s):   Category(s): Biotechnology

Enhancement of Proteasome Activity for the Treatment of Neurodegenerative Diseases

Executive SummaryAs we age, a decrease in the 20S proteasome’s activity level yields an increase in the accumulation and aggregation of toxic proteins, which are the classical hallmarks of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Artificial activation of the proteasome leads to a...
Published: 12/4/2017   |   Inventor(s): Jetze Tepe, Theresa Lansdell, Evert Njomen, Corey Jones
Keywords(s):   Category(s): Biotechnology

Enhancement of Oil Biosynthesis through Engineering of Plastid Lipases

Tech ID: TEC2017-0072
Published: 10/9/2017   |   Inventor(s): Christoph Benning, Kun Wang
Keywords(s):   Category(s): Biotechnology, Energy, Chemicals

Nicking Saturation Mutagenesis - a Fast and Kit-Compatible Method to Create Mutational Libraries

Executive SummaryThere is a huge interest in the research and pharmaceutical industry to improve protein properties by mutation. Enzyme and antibody engineering have become key areas of worldwide R&D activity in the private and university sector. The demand for simple, cheap, fast, and robust methods to prepare comprehensive mutagenesis librari...
Published: 8/18/2017   |   Inventor(s): Emily Wrenbeck, Timothy Whitehead, James Stapleton, Justin Klesmith
Keywords(s):   Category(s): Medical, Biotechnology

Drought Tolerance Gene

Executive SummaryMany current applications to control drought tolerance in plants are focusing on the manipulation of gene regulation. Researchers at MSU have discovered that over-expression of a gene that encodes a major regulator of plant cellular signaling processes creates a high level of drought tolerance. The over-expressing plants maintain l...
Published: 6/29/2017   |   Inventor(s): Robert Day, Patricia Santos, Caleb Knepper
Keywords(s):   Category(s): Agriculture, Biotechnology

Chemical Treatment for Osteoporosis

Executive SummaryCurrently available therapeutics for osteoporosis have the potential to produce severe negative side effects or are required to be administered via injection. Researchers at Michigan State University have developed a new therapeutic that overcomes these challenges.Description of TechnologyThis novel MSU technology uses high molecul...
Published: 6/28/2017   |   Inventor(s): Laura McCabe, Rifat Pamukcu
Keywords(s):   Category(s): Biotechnology, Pharmaceutical

Reducing Cultivation and Harvesting Costs for Cyanobacteria

Executive SummaryOur technology enables physical plant managers to control cyanobacterial flocculation, which significantly reduces recovery and dewatering requirements. These requirements alone account for up to 40% of operating costs in production of biofuels, pharmaceuticals, and chemicals from cyanobacteria. This technology works by inducing cy...
Published: 6/28/2017   |   Inventor(s): Daniel Ducat, Katherine Osteryoung, Joshua MacCready
Keywords(s):   Category(s): Biotechnology, Energy

Algae/Fungi Endosymbiosis Platform for Lipid Biosynthesis

Executive SummaryBioethanol and biodiesel are produced primarily from terrestrial plant material rich in sugar and starch such as corn, sugarcane, or sweet sorghum. However, producing fuels using food crops is not optimal in the long term since they require premium land, abundant water, and large inputs of energy in the form of agricultural machine...
Published: 6/16/2017   |   Inventor(s): Gregory Bonito, Zhi-Yan Du, Christoph Benning
Keywords(s):   Category(s): Energy, Agricultural, Chemicals, Biotechnology

Cyclic Peptide Production Enzymes and System

Executive SummaryCyclic peptides tend to be resistant to peptidases and therefore stable in vivo. Their size, chemical properties, and ability to interact with biomolecules suggest that they make good pharmaceutical and agricultural active ingredient candidates. However, intra-molecular cyclization is difficult and competes with unwanted inter-mol...
Published: 6/14/2017   |   Inventor(s): Jonathan Walton, Heather Hallen-Adams, John Scott-Craig, Hong Luo
Keywords(s):   Category(s): Biotechnology, Chemicals, Pharmaceutical
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