Search Results - Biotechnology

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A new forensic tool - Novel method of Identifying a Minor Contributor’s DNA in a Mixed Sample

Executive SummaryForensic scientists use an array of tools to identify individuals from a crime scene ranging from fingerprints to DNA. However, DNA evidence samples often contain DNA mixtures from both an assailant and a victim, which can either obscure one source or even render the entire evidence sample useless. The difficulty of de-convolving e...
Published: 7/9/2018   |   Inventor(s): David Foran, Katelyn Kranz
Keywords(s):   Category(s): Biotechnology

Co-culture solar production of high-value products utilizing encapsulated, carbohydrate-secreting cyanobacteria

Executive SummaryBiobased plastics and chemicals offer an alternative solution to products traditionally made from fossil fuel sources. Fermentation generally uses heterotrophic organisms to convert carbohydrate-rich feedstocks like sugarcane, sugar beets, and corn into value-added compounds (e.g nutritional supplements, pharmaceuticals, etc.). Bec...
Published: 6/18/2018   |   Inventor(s): Daniel Ducat, Taylor Weiss, Eric Young
Keywords(s):   Category(s): Biotechnology, Agricultural, Chemicals, Energy

Implantable Neural Microelectrodes and Fabrication Method

Executive SummaryMicroelectrodes have become vital in the current-day attempt to map and understand the human brain, as well as delivering unique therapeutic solutions. These microelectrodes are able to work as biosensors, picking up changes in potential and electrophysiology. In particular, extracellular sensors can record data on neurotransmitter...
Published: 6/4/2018   |   Inventor(s): Wen Li, Yue Guo, Thomas Schuelke, Michael Becker, Robert Rechenberg, Cory Rusinek
Keywords(s):   Category(s): Advanced Materials, Biotechnology, Devices

RF Detection of Analytes

Executive SummaryDue to public health concerns since the 1920’s, the U.S. dairy industry is federally required to be monitored and treated for bacterial contamination. Most municipalities mandate pasteurization to reduce the number of viable pathogens likely to cause disease. Pre- and post-pasteurized milk is often tested for contamination vi...

Novel MmpL3 Inhibitor as a Treatment of Mycobacterium Tuberculosis

Executive SummaryMycobacterium Tuberculosis (Mtb) is the pathogen responsible for Tuberculosis. Standard TB treatments typically require four different drugs and a duration of six to nine months of treatment; however, there is still an evolution of drug-resistant Mtb. With not only Tuberculosis, but drug-resistant Tuberculosis causing upwards of 1....
Published: 6/4/2018   |   Inventor(s): Robert Abramovitch, Huiqing Zheng
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Improved Technology for Mannitol Production

Executive SummaryIndustrialized production of mannitol for use as a food sweetener and various pharmaceutical applications is currently achieved by hydrogenation of a fructose/glucose syrup at high pressures and temperatures. The reaction produces a mixture of mannitol and sorbitol that is both inefficient (70% sorbitol as end-product) and requires...
Published: 5/31/2018   |   Inventor(s): Claire Vieille, Seung Hoon Song, J. Gregory Zeikus
Keywords(s):   Category(s): Chemicals, Biotechnology, Pharmaceutical

Novel Chemical Inhibitors of Mycobacterium Tuberculosis Targeting the DosRST Pathway – Tuberculosis Treatment

Executive SummaryTuberculosis (TB) is a potentially fatal infectious disease caused by the bacterium, Mycobacterium tuberculosis (Mtb). According to the Centers for Disease Control and Prevention (CDC), TB is one of the world’s deadliest diseases and responsible for upwards of 1.5 million deaths annually. TB is also a leading killer of HIV-in...
Published: 5/24/2018   |   Inventor(s): Robert Abramovitch, Edmund Ellsworth
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Adsorbed Polymer Coatings to Create Protein- and metal-Adsorbing Membranes

Executive SummaryTo rapidly purify proteins, one might derivatize membranes through growth of polymer brushes, however direct polymer adsorption is much simpler and essentially as effective. In this invention, MSU researchers deposit polymers that already contain metal-binding ligands, which greatly simplifies the procedure and reduces the waste of...
Published: 12/4/2017   |   Inventor(s): Merlin Bruening, Salinda Wijeratne, Wenjing Ning, Jinlan Dong, Weijing Liu
Keywords(s):   Category(s): Biotechnology

CH12F3 Cell Line with Various Knock-Outs

Executive SummaryThe CH12F3 mouse B lymphocyte cell lines are useful tools to study the role of DNA metabolism in modulating immunoglobulin genes and DNA repair. Since enzymes involved in DNA metabolism play essential roles in embryogenesis, knockout of these proteins often resulted in lethality in mouse embryonic stem cells. MSU researchers have d...
Published: 12/4/2017   |   Inventor(s): Kefei Yu
Keywords(s):   Category(s): Biotechnology

Enhancement of Proteasome Activity for the Treatment of Neurodegenerative Diseases

Executive SummaryAs we age, a decrease in the 20S proteasome’s activity level yields an increase in the accumulation and aggregation of toxic proteins, which are the classical hallmarks of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Artificial activation of the proteasome leads to a...
Published: 12/4/2017   |   Inventor(s): Jetze Tepe, Theresa Lansdell, Evert Njomen, Corey Jones
Keywords(s):   Category(s): Biotechnology
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