Search Results - nicholas+kanaan

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Recombinant Adeno-Associated Virus Capsid Mutants for Enhanced Transduction of Therapeutic Genetic Material in the CNS

Executive SummaryThe largest limiting factor in viral-mediated gene therapy is the efficacy of gene delivery to the target cells, which is dependent on the level of transduction. This becomes particularly important for therapies directly injected into the brain or central nervous system (CNS) as only a limited volume can be injected and the procedure...
Published: 12/12/2016   |   Inventor(s): Fredric Manfredsson, Nicholas Kanaan
Keywords(s):   Category(s): Medical

Novel Monoclonal Anti-NonPhosphoSer9 Glycogen Synthase Kinase 3 Beta Antibodies

Executive SummaryGlycogen synthase kinase 3beta (GSK3beta) is a serine/threonine kinase initially described for its role in regulating glycogen synthesis by phosphorylating and inactivating glycogen synthase following insulin exposure. This enzyme is expressed ubiquitously and is a critical downstream effector of the PI3K/AKT cell survival pathway....
Published: 10/17/2016   |   Inventor(s): Nicholas Kanaan, Tessa Grabinski
Keywords(s):   Category(s): Biotechnology

Nurr1 as a Genetic Target for Treating Levodopa-induced Dyskinesias (LIDs) in Parkinson's Disease

Executive SummaryPatients afflicted with Parkinson’s disease often develop severely debilitating movement disorders as side effects from currently available treatment options. Researchers at MSU propose to use a new gene therapy approach that will both reduce these side effects and prolong the effectiveness of treatment by targeted gene silencing.Description...
Published: 6/23/2016   |   Inventor(s): Fredric Manfredsson, Kathy Steece-Collier, Jack Lipton, Timothy Collier, Nicholas Kanaan, Caryl Sortwell
Keywords(s):   Category(s): Medical

Use of Sprr1 A-like Protein as a Neurorestorative and Neuroprotective Agent against Neurodegeneration in Parkinson's Disease

Executive SummaryAlthough the precise causes of Parkinson’s disease (PD) remain unclear, it has been long observed that those afflicted with the disease show widespread neurodegeneration of the central nervous system accompanied by a striking loss of dopamine producing neurons in the brain. Recent research suggests axonal degeneration of dopamine...
Published: 6/23/2016   |   Inventor(s): Nicholas Kanaan, Jack Lipton, Timothy Collier
Keywords(s):   Category(s): Medical

Genetic Targets and Gene Therapies for Treating Levodopa-induced Dyskinesias for Parkinsonisms

IntroductionThe Parkinson’s Disease Foundation estimates that there are 1.0 to 1.5 million people suffering from Parkinson’s disease (PD) in the United States alone. Those suffering from PD are afflicted with tremors in the limbs and face, rigidity and stiffness of the limbs and trunk, slowed movement, postural instability, and impaired...
Published: 4/9/2014   |   Inventor(s): Jack Lipton, Kathy Steece-Collier, Nicholas Kanaan, Timothy Collier, Fredric Manfredsson, Caryl Sortwell
Keywords(s):   Category(s): Medical, Pharmaceutical, Therapeutic