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Stretchable Bioelectronic Interface for Biopotential Recording

Executive Summary Flexible electronics are materials that are often soft and bendable which allow them to conform to various surfaces. One application for these is in the biomedical field where flexible electrodes are used to measure electrical signals such as an electrocardiogram (ECG), electroencephalogram (EEG), or electromyography (EMG). However,...
Published: 11/15/2023   |   Inventor(s): Jinxing Li, Vittorio Mottini
Keywords(s):   Category(s): Medical, Devices, Advanced Materials

Biocatalysis of Bioactive Taxanes

Executive Summary Chemotherapy drugs are critical for effective patient cancer care. Unfortunately, the pharmaceutical industry has encountered several instances where it has not been able to supply sufficient quantities of important chemotherapy drugs due to manufacturing problems. Michigan State University researchers have discovered a novel, faster...
Published: 10/2/2023   |   Inventor(s): Kevin Walker
Keywords(s):   Category(s): Medical, Pharmaceutical

Polyethylene Implants with Controlled Immune Response

Executive Summary Polyethylene is commonly used as a material for medical implants such as total joint replacements. Unfortunately, polyethylene wear particles can promote adverse host immune responses in patients, which may require secondary revision surgery. MSU researchers have recently discovered that metabolic reprogramming and altered bioenergetics...
Published: 8/16/2023   |   Inventor(s): Christopher Contag, Stuart Goodman, Chima Maduka
Keywords(s):   Category(s): Medical

Rapid Point of Care Detection of Tuberculosis

Executive Summary Tuberculosis (TB) remains one of the major causes of death from a single infectious agent worldwide, affecting both humans and livestock. Pulmonary TB can be currently diagnosed by various methods including chest radiography, sputum smear microscopy, nucleic acid amplification and cultivation of Mycobacterium tuberculosis (Mtb). However,...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja
Keywords(s):   Category(s): Medical, Biotechnology, Veterinary

Synthetic Implants with Controlled Immune Response

­ Executive Summary Polymers such as polylactic acid (PLA) are commonly used as bioabsorbable materials for implants. Unfortunately, degradation products from these often promote adverse host immune responses in patients, which may require a secondary medical intervention such as surgery to remove the implant. To attempt to counter this, some...
Published: 6/12/2023   |   Inventor(s): Chima Maduka, Christopher Contag
Keywords(s):   Category(s): Medical

Bioluminescent Dopamine and Glutamate Sensors

­ Executive Summary Genetically encoded optical sensors and advancements in microscopy have revolutionized the scientific toolbox used for answering complex biological questions especially in terms of studying brain activity. However, there remains a need to develop new tools for reporting neuronal activity in vivo within deeper structures. MSU...
Published: 2/17/2023   |   Inventor(s): Eric Petersen
Keywords(s):   Category(s): Medical, Biotechnology

Extracellular Vesicle Library for Drug Screening

­ Executive Summary The body’s natural transporter, Extracellular vesicles (EVs), have gained recent attention for their potential as targeted drug delivery vehicles with low immunogenic response. Properly designing the surface allows EVs to deliver therapeutic payloads (protein, RNA, nanoparticle, small molecule, etc.) to a target organ....
Published: 10/16/2023   |   Inventor(s): Christopher Contag, Masako Harada
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Mechanistic Basis of Pyrethrum Repellency Against Mosquitoes

­High-Throughput Screening Platform for Identification of Insect Repellents Executive Summary: High-throughput screening platform identifies repellent compounds that activate specific insect odor receptors. This platform can identify pyrethrins and pyrethroids to combine with odorant-mediated repellents to enhance overall repellant activity....
Published: 2/17/2023   |   Inventor(s): Ke Dong, Feng Liu, Qiang Wang, Peng Xu, Felipe Andreazza, Wilson Valbon
Keywords(s):   Category(s): Medical, Chemicals, Veterinary

Gold Nanoparticle Biosensors

Executive Summary Harmful microbes are present in a variety of sources including water, food, plants, and through human-to-human transmission. The ability to detect them rapidly at low cost is important to protecting the health and safety of humans and animals and the security of food chains. MSU researchers have developed novel gold (Au) nanoparticle...
Published: 5/22/2024   |   Inventor(s): Evangelyn Alocilja, Hanna Miller, Michael Anderson, Edith Torres-Chavolla
Keywords(s):   Category(s): Medical, Biotechnology, Food Science and Nutrition

Magnetic Nanoparticles, Magnetically Activated Cell Enrichment, and Biosensing

der-collapse: collapse; } Executive Summary Harmful microbes are present in a variety of sources including water, food, plants, environment, and through human-to-human transmission. The ability to detect them rapidly at low cost is important to protecting the health and safety of humans and animals and the security of food chains. MSU researchers...
Published: 5/22/2024   |   Inventor(s): Evangelyn Alocilja
Keywords(s):   Category(s): Medical, Biotechnology, Food Science and Nutrition
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