Search Results - fredric+manfredsson

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Recombinant Adeno-Associated Virus Capsid Mutants for Enhanced Transduction of Therapeutic Genetic Material in the CNS

Executive SummaryThe largest limiting factor in viral-mediated gene therapy is the efficacy of gene delivery to the target cells, which is dependent on the level of transduction. This becomes particularly important for therapies directly injected into the brain or central nervous system (CNS) as only a limited volume can be injected and the procedure...
Published: 6/8/2021   |   Inventor(s): Fredric Manfredsson, Nicholas Kanaan
Keywords(s):   Category(s): Medical

Nurr1 as a Genetic Target for Treating Levodopa-induced Dyskinesias (LIDs) in Parkinson's Disease

Executive SummaryPatients afflicted with Parkinson’s disease often develop severely debilitating movement disorders as side effects from currently available treatment options. Researchers at MSU propose to use a new gene therapy approach that will both reduce these side effects and prolong the effectiveness of treatment by targeted gene silencing.Description...
Published: 8/20/2022   |   Inventor(s): Fredric Manfredsson, Kathy Steece-Collier, Jack Lipton, Timothy Collier, Nicholas Kanaan, Caryl Sortwell
Keywords(s):   Category(s): Medical