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Biocatalytic production of MRI contrast agents

Executive Summary Herpes simplex virus type-1 thymidine kinase (HSV1-TK) is an enzyme that phosphorylates a wide range of nucleoside analogs, and has been used as a reporter gene with a variety of radiolabeled nucleotide analogs for positron emission tomography (PET). However, the complexity of synthesizing radiolabel probes and their short lifetime,...
Published: 8/5/2025   |   Inventor(s): Aimen Al-Hilfi, Assaf Gilad
Keywords(s): Medical Imaging, MRI Category(s): Medical, Chemicals