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Process for producing a Cyano ring-substituted Arene borane

Executive Summary In the pharmaceutical industry, organoboron complexes are key building blocks for drug manufacturing, versatile reagents for high-throughput parallel synthesis in drug discovery and exhibit some useful and unique biological activities. However, conventional synthesis routes can be complex and involve undesirable reagents. MSU researchers...
Published: 4/1/2024   |   Inventor(s): Milton Smith, Iii, Robert Maleczka, Ghayoor Chotana
Keywords(s):   Category(s): Chemicals, Pharmaceutical

Process for Chemical Recycling of Multilayer & Metallized Plastic Packaging Films

Executive Summary In order to combat the growth of global plastic waste, pyrolysis processes have been developed to turn this waste material into gases, oils and waxes. However, these processes usually require high operating temperatures, expensive catalysts and restrictions on the type of plastics they can handle. Researchers at Michigan State University...
Published: 10/11/2023   |   Inventor(s): Muhammad Rabnawaz, Mohamed Mohamed
Keywords(s):   Category(s): Chemicals, Recycling

Biosynthetic Route to Phloroglucinol Synthesis

Executive Summary: Phloroglucinol (1,3,5 trihydroxybenzene) is used in the production of a plethora of applications such as explosive or propellant compounds, medicaments, cosmetics, dyes, and others which make it such a sought-after resource. However, Phloroglucinol is difficult to synthesize by chemical synthesis and alternative routes are desired....
Published: 8/10/2023   |   Inventor(s): John Frost
Keywords(s):   Category(s): Chemicals, Pharmaceutical

Pyruvate-Based Pathway for Synthesis of 3-dehydroshikimate

Figure 1: (a) carbohydrate phosphotransferase; (b) KDPGal aldose, D-erythrose 4-phosphate; (c) DAHP synthase, D-erythrose 4-phosphate; (d) shikimate pathway enzymes. Executive Summary: 3-dehydroshikimate, a highly versatile compound that is currently limitedly produced, is used in supporting the creation of novel treatments of influenza...
Published: 8/10/2023   |   Inventor(s): John Frost
Keywords(s):   Category(s): Chemicals, Pharmaceutical

Boron Based Catalysts for Cycloaddition Reactions

Executive Summary Increasing there is greater interest in replacing petroleum based chemicals with bio-based alternatives. The packaging market in particular, has actively sought “greener” alternatives for important materials such as poly(ethylene terephthalate), a.k.a. PET. MSU researchers have developed a new catalyst and method to make...
Published: 8/1/2023   |   Inventor(s): John Frost, Peng Zhang
Keywords(s):   Category(s): Chemicals, Packaging

Carbon Supported Metal Catalyst

Executive Summary Metal based catalysts are used in a myriad of applications in chemical processing, waste exhaust treatment and others. The metals themselves can be extremely expensive and thus optimizing their effectiveness while minimizing use is critical. MSU researchers have developed a new method for producing nanoparticles of noble and transition...
Published: 6/16/2023   |   Inventor(s): Lawrence Drzal, Inhwan Do, Hiroyuki Fukushima
Keywords(s):   Category(s): Chemicals, Nanotechnology

Machining Lubricant Containing Exfoliated Graphite

Executive Summary Machining processes in high production environment usually adopt flood cooling with water-based lubricants and various chemicals. In order to minimize the lubricant use and waste (which also eliminate centralized pumping stations), minimum quantity lubrication (MQL) techniques have been adopted, which generate mist of oil droplets....
Published: 6/16/2023   |   Inventor(s): Patrick Kwon, Lawrence Drzal
Keywords(s):   Category(s): Nanotechnology, Chemicals, Materials

Efficient Room Temperature, Ambient Pressure Liquid Ammonia Storage System

Executive Summary Liquid ammonia is current stored and transported in very large quantities in refrigerated units, railcars, tanker trucks and pressurized containers. While the majority of existing uses are as a nitrogen fertilizer for agricultural uses, increasing attention has been turned to ammonia as a green, carbon free energy storage medium for...
Published: 5/17/2023   |   Inventor(s): Mi Chenija, Reza Ghazfar, Milton Smith, Iii, Thomas Hamann
Keywords(s):   Category(s): Chemicals, Agriculture, Energy, Environment, Transportation

Synthesis of Caprolactam from Lysine

Executive Summary Caprolactam is used in important polymer products such as the polyamide Nylon 6. Most Caprolactam is produced from petroleum based feedstocks and there is a desire for a more sustainable route for making the monomer. MSU researchers have developed a technology for synthesizing epsilon-caprolactam from L-lysine with yields up to 75%...
Published: 5/25/2023   |   Inventor(s): John Frost
Keywords(s):   Category(s): Chemicals, Environmental

Synthetic Bacterial Microcompartment Shell Proteins Derived by Circular Permutation and/or Genetic Fusion

INTRODUCTION Bacterial microcompartments (BMCs) are organelles used by various bacteria to encapsulate metabolic pathways into a proteinaceous shell. BMCs serve as scaffolds to organize encapsulated enzymes and as physical boundaries to reduce diffusive loss of volatile or toxic intermediates and restrict crosstalk with cytosolic biosynthetic pathways....
Published: 4/7/2023   |   Inventor(s): Cheryl Kerfeld, Bryan Ferlez, Markus Sutter, Andrew Hagen, Nancy Sloan
Keywords(s):   Category(s): Biotechnology, Energy, Chemicals, Environmental, Manufacturing Equipment
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