Search Results - jetze+tepe

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New Quinoline-Based Proteasome Inhibitors

Executive SummaryThere are several existing cancer treatments that are effective at inducing cell death by decreasing proteasome activity: Velcade® (bortezomib) and Kyprolis® (carfilzomib). Due to undesirable side effects and pharmacodynamics properties, these agents have been limited to treating blood cancers. MSU researchers have developed...
Published: 3/28/2024   |   Inventor(s): Aaron Odom, Jetze Tepe, Teri Lansdell
Keywords(s):   Category(s): Medical

Preparation of Hymenialdisine Derivatives and potential Application to Treatment of Inflammatory Diseases, Alzheimer's, and Cancer

IntroductionCyclin-dependent kinases and NF-kB regulate a large number of genes and biochemical pathways. Deviations in their activity are associated with diseases, including those linked to immune, inflammatory, and anti-apoptotic responses. Many areas of drug discovery are focused on discovery of reagents that inhibit their activities. Naturally occurring...
Published: 5/23/2023   |   Inventor(s): Jetze Tepe
Keywords(s): Anti-inflammatory, Hymenialdisine, Indolazepine, Kinase Inhibitors, NF-kB Inhibitors Category(s): Medical, Biotechnology, Pharmaceutical