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Search Results - edmund+ellsworth
Novel Rexinoid Agonists for Kras-mediated cancer and immunotherapy
Executive Summary:KRAS is one of the most common oncogenes that, when mutated, causes normal cells to become cancerous. Current therapeutics designed to block KRAS function have not shown favorable clinical outcomes and therefore, KRAS has been deemed an “undruggable” target. However, our studies demonstrate that novel, appropriately substituted...
Ana Sofia Leal
Biosynthesis of Chemically Diversified Non-Natural Terpene Products
Executive SummaryDrug and chemical discovery is a lengthy, difficult, and inefficient process. The production of new drugs and chemicals is bottlenecked at synthesis or biosynthesis of complicated molecules, especially chiral molecules. Furthermore, diversification of current drug and chemical libraries is hindered by these difficult and inefficient...
Björn (Bjoern) Hamberger
Novel Chemical Inhibitors of Mycobacterium Tuberculosis Targeting the DosRST Pathway – Tuberculosis Treatment
Executive SummaryTuberculosis (TB) is a potentially fatal infectious disease caused by the bacterium, Mycobacterium tuberculosis (Mtb). According to the Centers for Disease Control and Prevention (CDC), TB is one of the world’s deadliest diseases and responsible for upwards of 1.5 million deaths annually. TB is also a leading killer of HIV-infected...
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