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Search Results - jetze+tepe
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ID
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Enhancement of Proteasome Activity for the Treatment of Neurodegenerative Diseases
Executive SummaryAs we age, a decrease in the 20S proteasome’s activity level yields an increase in the accumulation and aggregation of toxic proteins, which are the classical hallmarks of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Artificial activation of the proteasome leads to an...
Published: 12/4/2017
|
Inventor(s):
Jetze Tepe
,
Theresa Lansdell
,
Evert Njomen
,
Corey Jones
Keywords(s):
Category(s):
Biotechnology
Novel Compounds to Treat Canine Histiocytic Sarcomas and Other Malignancies
Executive SummaryHistiocytic sarcomas are very aggressive and invasive tumors that occur with high incidence in Bernese Mountain dogs, Rottweilers, Flat Coated Retrievers, and Golden Retrievers. The prognosis of histiocytic sarcomas is poor with median survival time of a few weeks to a few months. The currently available clinical treatments, including...
Published: 8/10/2017
|
Inventor(s):
Vilma Yuzbasiyan-Gurkan
,
Jetze Tepe
Keywords(s):
Category(s):
Medical
,
Animal/Veterinary
,
Pharmaceutical
New Quinoline-Based Proteasome Inhibitors
Executive SummaryThere are several existing cancer treatments that are effective at inducing cell death by decreasing proteasome activity: Velcade® (bortezomib) and Kyprolis® (carfilzomib). Due to undesirable side effects and pharmacodynamics properties, these agents have been limited to treating blood cancers. MSU researchers have developed...
Published: 6/23/2016
|
Inventor(s):
Aaron Odom
,
Jetze Tepe
,
Theresa Lansdell
Keywords(s):
Category(s):
Medical
Preparation of Hymenialdisine Derivatives and potential Application to Treatment of Inflammatory Diseases, Alzheimer's, and Cancer
IntroductionCyclin-dependent kinases and NF-kB regulate a large number of genes and biochemical pathways. Deviations in their activity are associated with diseases, including those linked to immune, inflammatory, and anti-apoptotic responses. Many areas of drug discovery are focused on discovery of reagents that inhibit their activities. Naturally occurring...
Published: 9/24/2010
|
Inventor(s):
Jetze Tepe
Keywords(s):
Anti-inflammatory
,
Hymenialdisine
,
Indolazepine
,
Kinase Inhibitors
,
NF-kB Inhibitors
Category(s):
Medical
,
Biotechnology
,
Pharmaceutical
Novel Multi-Substituted Imidazolines with Potential Antimicrobial and Anti-inflammatory Application
Executive SummaryNF-kB is a transcription factor that regulates a large number of genes and biochemical pathways, including those involved in immune, inflammatory, and anti-apoptotic responses. Many areas of drug discovery are focused on developing reagents that regulate NF-kB. Imidazolines are potent inhibitors of NF-kB, and are currently being used...
Published: 9/24/2010
|
Inventor(s):
Jetze Tepe
,
Satyamaheshwar Peddibhotla
Keywords(s):
Anti-inflammatory
,
Anti-microbial
,
Chemopotentiator
,
Imidazoline
Category(s):
Medical
,
Biotechnology
,
Pharmaceutical
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