Search Results - aaron odom

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New Quinoline-Based Proteasome Inhibitors

Executive SummaryThere are several existing cancer treatments that are effective at inducing cell death by decreasing proteasome activity: Velcade® (bortezomib) and Kyprolis® (carfilzomib). Due to undesirable side effects and pharmacodynamics properties, these agents have been limited to treating blood cancers. MSU researchers have developed...
Published: 6/23/2016   |   Inventor(s): Aaron Odom, Jetze Tepe, Theresa Lansdall
Keywords(s):   Category(s): Medical

Efficient Catalytic Production of Isoamines for Pharmaceutical Applications

IntroductionA number of compounds used as intermediates in drug manufacture are difficult to produce. One such class of compounds is iminoamines. It would be desirable to have a way of easily manufacturing a wide variety of substituted iminoamines with good regioselectivity. This capability would make possible the production of a wide variety of chemical...
Published: 9/24/2010   |   Inventor(s): Aaron Odom
Keywords(s): 1-Azubutadienes, 3-Component Coupling, Beta-Unsaturated Beta-Iminoamines, Hydroamination, Isonitriles, Olefin Polymerization, Pyrrolyl Complex, Substituted Iminoamines, Titanium Catalysis Category(s): Chemicals, Materials, Pharmaceutical