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3DVARIENTVISION: DECODE FUNCTIONAL IMPACTS OF GENETIC VARIANTS BASED ON 3D CHROMATIN

VAlue proposition Deciphering the effects and mechanisms of genetic variants is essential to understand human genetics and further precision medicine. A genetic variant is a permanent change in the nucleotide sequence that makes up a gene, also known as a gene mutation. Mutations can cause diseases or phenotypic changes. Typically, Genome Wide Association...
Published: 4/9/2025   |   Inventor(s): Jianrong Wang, Jiaxin Yang
Keywords(s):   Category(s): Medical, Biotechnology, Computer Software

A.R.M.O.R. – A Tool for Evaluating Polypharmacy

Executive Summary Many patients, especially the elderly, are on various forms of medication, leading to higher risks of adverse drug reactions (ADRs) and drug-drug interactions (DDIs). Addressing this complex issue of polypharmacy requires collation of multiple factors, including patient clinical profiles, functional status, and evidence-based data...
Published: 10/25/2024   |   Inventor(s): Raza Haque
Keywords(s):   Category(s): Medical, Education & Training

Harmonic RF Tag for Wireless Measurement of Multiple Products

VALUE PROPOSITION It is desirable to remotely detect and measure the motions of objects in living spaces for applications such as human-computer interaction and connected homes. Furthermore, home health and remote diagnostic applications have seen dramatically increased demand as people look for solutions to health care that do not require leaving...
Published: 8/15/2024   |   Inventor(s): Jeffrey Nanzer, Corwin Hilton, Neda Nourshamsi
Keywords(s):   Category(s): Medical, Informatics

Detection and Prediction of Mild Cognitive Impairment using Resting-State EEG

VALUE PROPOSITION Early discrimination and prediction of mild cognitive impairment (MCI) are crucial for the study of neurodegenerative mechanisms and interventions to promote cognitive resiliency. Existing work mainly focuses on the detection of MCI before Alzheimer’s onset; however, quantitative methods which enable prediction of progression...
Published: 8/13/2024   |   Inventor(s): Tongtong Li, Jinxian Deng, Boxin Sun, Bruno Giordani, Mingyan Liu, Voyko Kavcic
Keywords(s):   Category(s): Medical

Spectroscopic Bioagent Detection

VALUE PROPOSITION The need for Identifying viruses quickly and accurately has become more apparent than ever. Each cell, virus, nanoparticle vibrates at a natural frequency. This technology is a phonon spectroscopy-based microscope that accurately identifies single nanoparticles and viruses. The device can be used for detecting single viruses or...
Published: 9/24/2024   |   Inventor(s): Elad Harel
Keywords(s):   Category(s): Medical, Analytical Instruments, Biotechnology, Environmental, Photonics

Therapeutic for Tissue Healing and Resistive Bacteria

INTRODUCTION Healing infected tissue and combating resistant bacteria are significant clinical challenges. Antibiotic-based therapies are increasingly unsuccessful due to the ability of pathogens to develop resistance. Methicillin resistant Staphylococcus aureus (MRSA), for example, is a leading cause of many infections, including skin and soft tissue...
Published: 1/24/2025   |   Inventor(s): Xanthippi Chatzistavrou, Neal Hammer
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

MRI RF Powered Voltage Sensor

VALUE PROPOSITION For Magnetic Resonance Imaging it is often desirable to measure electrophysical characteristics alongside MRI data. To do so, voltage sensors are employed. This technology is an RF powered voltage sensor which can be configurable to measure a variety of physical indicators with excellent resolution. The design minimizes interference...
Published: 7/29/2024   |   Inventor(s): Chunqi Qian
Keywords(s):   Category(s): Medical, Test and Measurement, Biotechnology

Stretchable Bioelectronic Interface for Biopotential Recording

Executive Summary Flexible electronics are materials that are often soft and bendable which allow them to conform to various surfaces. One application for these is in the biomedical field where flexible electrodes are used to measure electrical signals such as an electrocardiogram (ECG), electroencephalogram (EEG), or electromyography (EMG). However,...
Published: 11/15/2023   |   Inventor(s): Jinxing Li, Vittorio Mottini
Keywords(s):   Category(s): Medical, Devices, Advanced Materials

Biocatalysis of Bioactive Taxanes

Executive Summary Chemotherapy drugs are critical for effective patient cancer care. Unfortunately, the pharmaceutical industry has encountered several instances where it has not been able to supply sufficient quantities of important chemotherapy drugs due to manufacturing problems. Michigan State University researchers have discovered a novel, faster...
Published: 10/2/2023   |   Inventor(s): Kevin Walker
Keywords(s):   Category(s): Medical, Pharmaceutical

Polyethylene Implants with Controlled Immune Response

Executive Summary Polyethylene is commonly used as a material for medical implants such as total joint replacements. Unfortunately, polyethylene wear particles can promote adverse host immune responses in patients, which may require secondary revision surgery. MSU researchers have recently discovered that metabolic reprogramming and altered bioenergetics...
Published: 9/18/2024   |   Inventor(s): Christopher Contag, Stuart Goodman, Chima Maduka
Keywords(s):   Category(s): Medical
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