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Rapid Point of Care Detection of Tuberculosis

Executive Summary Tuberculosis (TB) remains one of the major causes of death from a single infectious agent worldwide, affecting both humans and livestock. Pulmonary TB can be currently diagnosed by various methods including chest radiography, sputum smear microscopy, nucleic acid amplification and cultivation of Mycobacterium tuberculosis (Mtb). However,...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja
Keywords(s):   Category(s): Medical, Biotechnology, Veterinary

Synthetic Implants with Controlled Immune Response

­ Executive Summary Polymers such as polylactic acid (PLA) are commonly used as bioabsorbable materials for implants. Unfortunately, degradation products from these often promote adverse host immune responses in patients, which may require a secondary medical intervention such as surgery to remove the implant. To attempt to counter this, some...
Published: 5/10/2023   |   Inventor(s): Chima Maduka, Chris Contag
Keywords(s):   Category(s): Medical

Bioluminescent Dopamine and Glutamate Sensors

­ Executive Summary Genetically encoded optical sensors and advancements in microscopy have revolutionized the scientific toolbox used for answering complex biological questions especially in terms of studying brain activity. However, there remains a need to develop new tools for reporting neuronal activity in vivo within deeper structures. MSU...
Published: 2/17/2023   |   Inventor(s): Eric Petersen
Keywords(s):   Category(s): Medical, Biotechnology

Extracellular Vesicle Library for Drug Screening

­ Executive Summary The body’s natural transporter, Extracellular vesicles (EVs), have gained recent attention for their potential as targeted drug delivery vehicles with low immunogenic response. Properly designing the surface allows EVs to deliver therapeutic payloads (protein, RNA, nanoparticle, small molecule, etc.) to a target organ....
Published: 3/11/2023   |   Inventor(s): Chris Contag, Masako Harada
Keywords(s):   Category(s): Medical, Biotechnology, Pharmaceutical

Mechanistic Basis of Pyrethrum Repellency Against Mosquitoes

­High-Throughput Screening Platform for Identification of Insect Repellents Executive Summary: High-throughput screening platform identifies repellent compounds that activate specific insect odor receptors. This platform can identify pyrethrins and pyrethroids to combine with odorant-mediated repellents to enhance overall repellant activity....
Published: 2/17/2023   |   Inventor(s): Ke Dong, Feng Liu, Qiang Wang, Peng Xu, Felipe Andreazza, Wilson Valbon
Keywords(s):   Category(s): Medical, Chemicals, Veterinary

Gold Nanoparticle Biosensors

Executive Summary Harmful microbes are present in a variety of sources including water, food, plants, and through human-to-human transmission. The ability to detect them rapidly at low cost is important to protecting the health and safety of humans and animals and the security of food chains. MSU researchers have developed novel gold (Au) nanoparticle...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja, Hanna Miller, Michael Anderson, Edith Torres-Chavolla
Keywords(s):   Category(s): Medical, Biotechnology, Food Science and Nutrition

Magnetic Nanoparticles, Magnetically Activated Cell Enrichment, and Biosensing

der-collapse: collapse; } Executive Summary Harmful microbes are present in a variety of sources including water, food, plants, environment, and through human-to-human transmission. The ability to detect them rapidly at low cost is important to protecting the health and safety of humans and animals and the security of food chains. MSU researchers...
Published: 2/17/2023   |   Inventor(s): Evangelyn Alocilja
Keywords(s):   Category(s): Medical, Biotechnology, Food Science and Nutrition

Hybrid Gelatin Methacryloyl-Silver Bioactive Glass Bioink

­Executive Summary Three dimensional (3D) bioprinting is an emerging field that involves producing tissue structures with 3D printing techniques. Examples include bone tissue/fillers, synthetic skin, scaffolds for drug delivery and tissues for dental repair. Common 3D bioprinting methods include extrusion, stereolithography and microfluidics-based...
Published: 4/7/2023   |   Inventor(s): Nureddin Shammakhi, Xanthippi Chatzistavrou
Keywords(s):   Category(s): Medical, Advanced Materials, Nanotechnology, Pharmaceutical

Recombinant Protein for Rare Earth Element Binding

Executive Summary Rare earth elements (REEs) are essential materials used in advanced technologies such as electronics, process catalysts, magnets, batteries and MRI contrast agents. Although used in small quantities for each application, they end up in surface water and soil during mining, processing and waste disposal. This presents growing environmental...
Published: 4/7/2023   |   Inventor(s): Harvey Lee, Connor Grady, Assaf Gilad
Keywords(s):   Category(s): Medical, Biotechnology, Environment, Test and Measurement

Microfluidic Apparatus For Respirometry

Executive Summary Cellular respiration is a set of metabolic processes responsible for the conversion of chemical energy in all aerobic organisms. In animal and plant cells this takes place in the mitochondria where food is broken down to CO2 and strongly reducing compounds. Energy released upon oxidation of the latter by molecular oxygen via a chain...
Published: 2/17/2023   |   Inventor(s): Denis Proshlyakov, Julia Busik
Keywords(s):   Category(s): Medical, Devices, Pharmaceutical, Test and Measurement, Biotechnology
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