Search Results - Biotechnology

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Engineered Shell Proteins to Enable Electron Transfer Across the Shell of a Bacterial Microcompartment

INTRODUCTION Bacterial microcompartments (BMCs) are organelles used by various bacteria to encapsulate metabolic pathways into a proteinaceous shell. Because of their attributes (self-assembling modules, optimization of the reactions in their lumen.) they have potential as catalytic bioreactors that can be customized to support new metabolic functions....
Published: 3/3/2021   |   Inventor(s): Cheryl Kerfeld, Clement Aussignargues
Keywords(s):   Category(s): Biotechnology, Chemicals, Energy, Environmental, Manufacturing Equipment

Viridiflorol Production

INTRODUCTION: Viridiflorol is a terpene bioproduct that has been isolated from the essential oils of a variety of plants including Melaleuca quinquenervia (broad-leaved paperbark). Terpenes make up a large class of natural plant products with applications that range from fragrances, cosmetics, to agrichemicals, insecticides and pharmaceuticals. The...

Surface TSPO in blood cells: Biomarker of peripheral and brain inflammation

INTRODUCTIONTranslocator Protein 18kDa (TSPO) is a nuclear encoded outer mitochondrial membrane protein that is ubiquitously expressed by most host cells. Initially, TSPO was a diazepam target, but it has also been referred to as an ‘orphan protein searching for a function’. Since the generation of these knockouts, TSPO has been determined...
Published: 8/10/2020   |   Inventor(s): Norbert Kaminski, Robert Crawford, Lance Blevins
Keywords(s):   Category(s): Medical, Biotechnology, Test and Measurement

Genetic Engineering of Oils In Vegetable (Non-Seed) Tissues By Diverting Carbon From Starch

INTRODUCTIONTriacylglycerol (TAG) is an ester that is derived from three fatty acids and glycerol. Triglycerides are the main constituents vegetable oil. Generally, in an oil crop species, TAG is produced in seeds, and this TAG can be harvested for various uses. TAG from plant oils are used as feedstocks for biofuels, food and industrial chemicals....
Published: 5/22/2020   |   Inventor(s): Christoph Benning, Sanjaya Sanjaya
Keywords(s):   Category(s): Biotechnology, Agriculture

Evolution Of Models To Predict Protein Function Using Genetic Programming

INTRODUCTIONGenetic Programming (GP) follows the concept put forth by Darwin – “Survival of the Fittest”. Species that evolve and adapt in response to the environment are more likely to survive. GP evolves models that can optimize peptides and proteins for variety of applications. It requires only basic understanding in protein engineering....

Biosynthesis of Chemically Diversified Non-Natural Terpene Products

Executive SummaryDrug and chemical discovery is a lengthy, difficult, and inefficient process. The production of new drugs and chemicals is bottlenecked at synthesis or biosynthesis of complicated molecules, especially chiral molecules. Furthermore, diversification of current drug and chemical libraries is hindered by these difficult and inefficient...
Published: 1/8/2020   |   Inventor(s): Edmund Ellsworth, Matthew Giletto, Björn (Bjoern) Hamberger, Garret Miller, Richard Neubig
Keywords(s):   Category(s): Biotechnology, Chemicals

Transcription factors to improve plant resistance to insects

Executive SummaryAs sessile organisms, plants must be able to adapt swiftly to biotic and environmental stimuli, and often do this through transcriptional reprogramming. Upon wounding by a ravenous insect, for instance, jasmonic acid (JA) increases in concentration within a cell and interacts with members of the JAZ family of repressor proteins. Ultimately,...
Published: 7/16/2019   |   Inventor(s): Gregg Howe, Marcelo Campos, Yuki Yoshida
Keywords(s):   Category(s): Biotechnology, Agriculture

Method for Improved Production of Terpenoids Using Co-Engineered Lipid Droplets and Anchoring of Terpene Biosynthetic Enzymes on Their Surface

Executive SummaryThis technology addresses one of the main hurdles of plant production and extraction of terpenoids by capturing desired terpenes in lipid droplets in plant cells. The lipid droplets are readily extracted using standard processes used in the vegetable oil and biodiesel industries, and the high-value terpenes can be easily separated...
Published: 5/28/2019   |   Inventor(s): Björn (Bjoern) Hamberger, Radin Sadre, Christoph Benning, Jacob Bibik
Keywords(s):   Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical

Method for Production of Novel Diterpene Scaffolds

Executive SummaryMany insecticides currently in use are problematic due to persistence in the environment and off target effects including accumulation in apex predator species. Therefore effective crop-protecting agents that are naturally sourced and that overcome some of these side effects are under increasing demand. This technology identifies biosynthetic...
Published: 5/28/2019   |   Inventor(s): Björn (Bjoern) Hamberger, Sean Johnson, Wajid Bhat
Keywords(s):   Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical

Two Phase Consortium for Production of Metabolites from a Cyanobacteria/Bacteria Mixed Consortium

Executive SummaryBiobased plastics and chemicals offer an alternative solution to products traditionally made from fossil fuel sources. Bioindustries utilize heterotrophic organisms to convert carbohydrate-rich feedstocks like sugarcane, sugar beets, and corn into value-added compounds (e.g. nutritional supplements, pharmaceuticals, etc.). Because these...
Published: 5/28/2019   |   Inventor(s): Daniel Ducat, Taylor Weiss, Eric Young
Keywords(s):   Category(s): Biotechnology, Agricultural, Chemicals, Energy
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