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Microfluidic Apparatus For Respirometry

Executive Summary Cellular respiration is a set of metabolic processes responsible for the conversion of chemical energy in all aerobic organisms. In animal and plant cells this takes place in the mitochondria where food is broken down to CO2 and strongly reducing compounds. Energy released upon oxidation of the latter by molecular oxygen via a chain...

Published: 10/20/2021 | Inventor(s): Denis Proshlyakov, Julia Busik

Keywords(s): Category(s): Medical, Devices, Pharmaceutical, Test and Measurement, Biotechnology

Antibacterial Silicate Glass-Ceramic Filament for 3D Printing Bone Materials

INTRODUCTION The use of 3D printed porous scaffolds provides a multi-dimensional template that closely mimics the native structure of bone. This is beneficial for creating ideal conditions for bone tissue regeneration. Silicate bioactive glass-ceramics are inherently bioconductive and bioinductive, making them ideal for tissue regeneration. DESCRIPTION...

Published: 6/14/2021 | Inventor(s): Aljoscha Roch NO LONGER AT MSU, Xanthippi Chatzistavrou

Keywords(s): Category(s): Medical, Biotechnology, Pharmaceutical

Therapeutic for Tissue Healing and Resistive Bacteria

INTRODUCTION Healing infected tissue and combating resistant bacteria are significant clinical challenges. Antibiotic-based therapies are increasingly unsuccessful due to the ability of pathogens to develop resistance. Methicillin resistant Staphylococcus aureus (MRSA), for example, is a leading cause of many infections, including skin and soft tissue...

Published: 6/14/2021 | Inventor(s): Xanthippi Chatzistavrou, Neal Hammer

Keywords(s): Category(s): Medical, Biotechnology, Pharmaceutical

Engineered Shell Proteins to Enable Electron Transfer Across the Shell of a Bacterial Microcompartment

INTRODUCTION Bacterial microcompartments (BMCs) are organelles used by various bacteria to encapsulate metabolic pathways into a proteinaceous shell. Because of their attributes (self-assembling modules, optimization of the reactions in their lumen.) they have potential as catalytic bioreactors that can be customized to support new metabolic functions....

Published: 3/3/2021 | Inventor(s): Cheryl Kerfeld, Clement Aussignargues

Keywords(s): Category(s): Biotechnology, Chemicals, Energy, Environmental, Manufacturing Equipment

Viridiflorol Production

INTRODUCTION: Viridiflorol is a terpene bioproduct that has been isolated from the essential oils of a variety of plants including Melaleuca quinquenervia (broad-leaved paperbark). Terpenes make up a large class of natural plant products with applications that range from fragrances, cosmetics, to agrichemicals, insecticides and pharmaceuticals. The...

Published: 2/16/2021 | Inventor(s): Björn (Bjoern) Hamberger, Wajid Bhat, E. Sean Johnson, Fani Ntana, David Collinge, F. Birgit Jensen, G. Hans Jorgen Jorgensen

Keywords(s): Category(s): Biotechnology, Chemicals, Flavorings and Fragrances

Surface TSPO in blood cells: Biomarker of peripheral and brain inflammation

INTRODUCTIONTranslocator Protein 18kDa (TSPO) is a nuclear encoded outer mitochondrial membrane protein that is ubiquitously expressed by most host cells. Initially, TSPO was a diazepam target, but it has also been referred to as an ‘orphan protein searching for a function’. Since the generation of these knockouts, TSPO has been determined...

Published: 8/10/2020 | Inventor(s): Norbert Kaminski, Robert Crawford, Lance Blevins

Keywords(s): Category(s): Medical, Biotechnology, Test and Measurement

Genetic Engineering of Oils In Vegetable (Non-Seed) Tissues By Diverting Carbon From Starch

INTRODUCTIONTriacylglycerol (TAG) is an ester that is derived from three fatty acids and glycerol. Triglycerides are the main constituents vegetable oil. Generally, in an oil crop species, TAG is produced in seeds, and this TAG can be harvested for various uses. TAG from plant oils are used as feedstocks for biofuels, food and industrial chemicals....

Published: 5/22/2020 | Inventor(s): Christoph Benning, Sanjaya Sanjaya

Keywords(s): Category(s): Biotechnology, Agriculture

Evolution Of Models To Predict Protein Function Using Genetic Programming

INTRODUCTIONGenetic Programming (GP) follows the concept put forth by Darwin – “Survival of the Fittest”. Species that evolve and adapt in response to the environment are more likely to survive. GP evolves models that can optimize peptides and proteins for variety of applications. It requires only basic understanding in protein engineering....

Published: 5/6/2020 | Inventor(s): Assaf Gilad, Wolfgang Banzhaf, Alexander Bricco, Iliya Miralavykomsari

Keywords(s): Category(s): Biotechnology, Computer Software, Data Processing/Analysis, Pharmaceutical, Therapeutic

Biosynthesis of Chemically Diversified Non-Natural Terpene Products

Executive SummaryDrug and chemical discovery is a lengthy, difficult, and inefficient process. The production of new drugs and chemicals is bottlenecked at synthesis or biosynthesis of complicated molecules, especially chiral molecules. Furthermore, diversification of current drug and chemical libraries is hindered by these difficult and inefficient...

Published: 1/8/2020 | Inventor(s): Edmund Ellsworth, Matthew Giletto, Björn (Bjoern) Hamberger, Garret Miller, Richard Neubig

Keywords(s): Category(s): Biotechnology, Chemicals

Transcription factors to improve plant resistance to insects

Executive SummaryAs sessile organisms, plants must be able to adapt swiftly to biotic and environmental stimuli, and often do this through transcriptional reprogramming. Upon wounding by a ravenous insect, for instance, jasmonic acid (JA) increases in concentration within a cell and interacts with members of the JAZ family of repressor proteins. Ultimately,...

Published: 7/16/2019 | Inventor(s): Gregg Howe, Marcelo Campos, Yuki Yoshida