Cockroach Sodium Channel Clones

­Insect Sodium Channel Clones for Insecticide Research and Development


Executive Summary:

Well-characterized insect sodium channel clones useful for insecticide research and development.



Sodium channels are well-known targets for a variety of widely-used and relatively safe insecticides, such as pyrethroid insecticides (e.g., bifenthrin and cyfluthrin). Thus, understanding the function and structure of these sodium channels are important for insecticide research and development.


Description of Technology:

These insect sodium channel clones were isolated from the cockroach (Blattella germanica) genome for expression and characterization in Xenopus oocytes. These sodium channel clones can be used for insecticide research and development.


Key Benefits

  • Well-characterized insect sodium channel clones for expression in Xenopus oocytes


Applications: Insecticide research and development


Related publications:

Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. Du et al., Biochem. J. 2009.

A Voltage-Gated Calcium-Selective Channel Encoded by a Sodium Channel-like Gene. Zhou et al., Neuron. 2004.

RNA Editing Generates Tissue-specific Sodium Channels with Distinct Gating Properties. Song et al., J Biol. Chem. 2004.

Alternative Splicing of an Insect Sodium Channel Gene Generates Pharmacologically Distinct Sodium Channels. Tan et al., J. Neurosci. 2002.


Protection Status: None


Tech ID: TEC2021-0070, TEC2006-0069, TEC2006-0056


Patent Information:

For Information, Contact:

Julia Miller
AgBio Technology Manager
Michigan State University