Cockroach Sodium Channel Clones
Insect Sodium Channel Clones for Insecticide Research and Development
Well-characterized insect sodium channel clones useful for insecticide research and development.
Sodium channels are well-known targets for a variety of widely-used and relatively safe insecticides, such as pyrethroid insecticides (e.g., bifenthrin and cyfluthrin). Thus, understanding the function and structure of these sodium channels are important for insecticide research and development.
Description of Technology:
These insect sodium channel clones were isolated from the cockroach (Blattella germanica) genome for expression and characterization in Xenopus oocytes. These sodium channel clones can be used for insecticide research and development.
- Well-characterized insect sodium channel clones for expression in Xenopus oocytes
Applications: Insecticide research and development
Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. Du et al., Biochem. J. 2009. https://doi.org/10.1042/BJ20082082
A Voltage-Gated Calcium-Selective Channel Encoded by a Sodium Channel-like Gene. Zhou et al., Neuron. 2004. https://doi.org/10.1016/S0896-6273(04)00148-5
RNA Editing Generates Tissue-specific Sodium Channels with Distinct Gating Properties. Song et al., J Biol. Chem. 2004. https://doi.org/10.1074/jbc.M402392200
Alternative Splicing of an Insect Sodium Channel Gene Generates Pharmacologically Distinct Sodium Channels. Tan et al., J. Neurosci. 2002. https://doi.org/10.1523/JNEUROSCI.22-13-05300.2002
Protection Status: None
Tech ID: TEC2021-0070, TEC2006-0069, TEC2006-0056
For Information, Contact:
AgBio Technology Manager
Michigan State University