Exhaled Breath Analyzer for Lung Transplant Monitoring


Executive Summary


Lung transplantation is a therapeutic option for patients suffering from the end stage of various lung diseases. Monitoring for signs of rejection is an invasive process that requires biopsies of a small portion of the lung. A new MSU technology allows for the monitoring of lung transplant rejection through biomarkers in the patient’s breath.


Description of Technology


This MSU technology is a combined sensor that detects peroxynitrite and nitric oxide levels. The patient breathes into the portable device and a multichannel potentiostat allows for the detection of these biomarkers. High levels of these species are indicative of lung transplant rejection.


Key Benefits

  • Non-invasive: enables lung transplant monitoring without invasive and expensive lung biopsies
  • Combined sensor: allows for detection of both NO and peroxynitrite
  • Portable: can be easily utilized in clinical setting
  • Reusable: only have to change the disposable filter



  • Lung transplantation: can detect early stages of acute or chronic lung transplant rejection
  • Lung cancer diagnosis: excessive production of reactive oxygen species is found in lung cancer patients


Patent Status: 


Patent pending.


Licensing Rights Available


Full licensing rights available.


Inventors: Dr. Greg Swain, Serban Peteu, and Dr. Borys Hrinczenko


Tech ID: TEC2016-0135


Patent Information:


For Information, Contact:

Anupam Jhingran
Technology Manager
Michigan State University