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Engineered Shell Proteins to Enable Electron Transfer Across the Shell of a Bacterial Microcompartment

INTRODUCTION Bacterial microcompartments (BMCs) are organelles used by various bacteria to encapsulate metabolic pathways into a proteinaceous shell. Because of their attributes (self-assembling modules, optimization of the reactions in their lumen.) they have potential as catalytic bioreactors that can be customized to support new metabolic functions....
Published: 3/3/2021   |   Inventor(s): Cheryl Kerfeld, Clement Aussignargues
Keywords(s):   Category(s): Biotechnology, Chemicals, Energy, Environmental, Manufacturing Equipment

Viridiflorol Production

INTRODUCTION: Viridiflorol is a terpene bioproduct that has been isolated from the essential oils of a variety of plants including Melaleuca quinquenervia (broad-leaved paperbark). Terpenes make up a large class of natural plant products with applications that range from fragrances, cosmetics, to agrichemicals, insecticides and pharmaceuticals. The...

Degradable Unimolecular Nanoparticles

Executive Summary Biodegradable polymers are useful as drug delivery agents. MSU researchers have developed a poly(glycolide) based polymer that forms unimolecular micelles with diameters less than 50 nm. These nanoparticles contain functional groups which provide anchoring sites for drugs, contrast agents or other biological agents. Description of...
Published: 10/26/2020   |   Inventor(s): Gregory Baker, Erin Vogel, Milton Smith, Iii
Keywords(s):   Category(s): Chemicals, Materials, Pharmaceutical, Nanotechnology

Mesoporous MFI-Zeolite Catalysts for Aromatics Production

Executive SummaryThere is a need for a green, renewable, and sustainable route to produce chemicals currently made from petrochemical feedstocks. MSU researchers have developed a new catalyst system for converting biomass to aromatics. The aromatics can be further transformed into downstream chemicals such as terephthalic acid, which can be used in...
Published: 10/16/2020   |   Inventor(s): Shantanu Kelkar, Christopher Saffron, Thomas Pinnavaia, Robert Kriegel
Keywords(s):   Category(s): Chemicals, Environment, Agricultural

Vapor Effect Reduction from Volatile Herbicides

IntroductionDicamba and 2,4-D are growth-regulator herbicides that provide excellent broad-leaf weed control. Recently released trait genes allow for wide scale use of these herbicides over broad-leaf crops. Unfortunately, both dicamba and 2,4-D are known to have a high vapor pressure, which, under the wrong conditions, may lead to a cloud of herbicide...
Published: 5/7/2020   |   Inventor(s): Donald Penner
Keywords(s):   Category(s): Chemicals, Agricultural

Small Molecule Inhibitors For The Treatment Of Proteinopathies

INTRODUCTIONProtein aggregation that leads to plaque formation is a contributor in many degenerative diseases including Alzheimer’s, Parkinson’s, Type 2 diabetes, and other amyloidosis diseases. Once these plaques are formed, they are extremely difficult to degrade. Breakdown and even inhibition of oligomers before formation of these plaques...
Published: 5/6/2020   |   Inventor(s): Jessica Fortin
Keywords(s):   Category(s): Medical, Chemicals, Pharmaceutical

Tunable Luminescent Organic Salts for Enhanced Imaging and Photodynamic Therapy

Executive Summary:Theranostic nanomedicine, the medical application of nanobiotechnology, is an emerging area of cancer research. These nanosystems are capable of diagnosing, curing, or preventing diseases. One example of theranostic nanomedicine is photodynamic therapy which uses photosensitizing agents with light to kill cancer cells. However, a major...

Biosynthesis of Chemically Diversified Non-Natural Terpene Products

Executive SummaryDrug and chemical discovery is a lengthy, difficult, and inefficient process. The production of new drugs and chemicals is bottlenecked at synthesis or biosynthesis of complicated molecules, especially chiral molecules. Furthermore, diversification of current drug and chemical libraries is hindered by these difficult and inefficient...
Published: 1/8/2020   |   Inventor(s): Edmund Ellsworth, Matthew Giletto, Bjoern Hamberger, Garret Miller, Richard Neubig
Keywords(s):   Category(s): Biotechnology, Chemicals

Method for Improved Production of Terpenoids Using Co-Engineered Lipid Droplets and Anchoring of Terpene Biosynthetic Enzymes on Their Surface

Executive SummaryThis technology addresses one of the main hurdles of plant production and extraction of terpenoids by capturing desired terpenes in lipid droplets in plant cells. The lipid droplets are readily extracted using standard processes used in the vegetable oil and biodiesel industries, and the high-value terpenes can be easily separated...
Published: 5/28/2019   |   Inventor(s): Björn (Bjoern) Hamberger, Radin Sadre, Christoph Benning, Jacob Bibik
Keywords(s):   Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical

Method for Production of Novel Diterpene Scaffolds

Executive SummaryMany insecticides currently in use are problematic due to persistence in the environment and off target effects including accumulation in apex predator species. Therefore effective crop-protecting agents that are naturally sourced and that overcome some of these side effects are under increasing demand. This technology identifies biosynthetic...
Published: 5/28/2019   |   Inventor(s): Björn (Bjoern) Hamberger, Sean Johnson, Wajid Bhat
Keywords(s):   Category(s): Agriculture, Chemicals, Biotechnology, Pharmaceutical
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