Available Technologies

­Insect Sodium Channel Clones for Insecticide Research and Development

Executive Summary:

Well-characterized insect sodium channel clones useful for insecticide research and development.

Background:

Sodium channels are well-known targets for a variety of widely-used and relatively safe insecticides, such as pyrethroid insecticides (e.g., bifenthrin and cyfluthrin). Thus, understanding the function and structure of these sodium channels are important for insecticide research and development.

Description of Technology:

These insect sodium channel clones were isolated from the cockroach (Blattella germanica) genome for expression and characterization in Xenopus oocytes. These sodium channel clones can be used for insecticide research and development.

Key Benefits

• Well-characterized insect sodium channel clones for expression in Xenopus oocytes

Applications: Insecticide research and development

Related publications:

Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. Du et al., Biochem. J. 2009. https://doi.org/10.1042/BJ20082082

A Voltage-Gated Calcium-Selective Channel Encoded by a Sodium Channel-like Gene. Zhou et al., Neuron. 2004. https://doi.org/10.1016/S0896-6273(04)00148-5

RNA Editing Generates Tissue-specific Sodium Channels with Distinct Gating Properties. Song et al., J Biol. Chem. 2004. https://doi.org/10.1074/jbc.M402392200

Alternative Splicing of an Insect Sodium Channel Gene Generates Pharmacologically Distinct Sodium Channels. Tan et al., J. Neurosci. 2002. https://doi.org/10.1523/JNEUROSCI.22-13-05300.2002

Protection Status: None

Tech ID: TEC2021-0070, TEC2006-0069, TEC2006-0056