Available Technologies

Executive Summary

To rapidly purify proteins, one might derivatize membranes through growth of polymer brushes, however direct polymer adsorption is much simpler and essentially as effective. In this invention, MSU researchers deposit polymers that already contain metal-binding ligands, which greatly simplifies the procedure and reduces the waste of expensive ligands. This innovative adsorption procedure is a new way to modify membranes to either facilitate rapid protein purification with membranes or immobilize proteins to create an enzymatic reactor.

Description of Technology

Layer-by-layer adsorption on solid surfaces and on surfaces of membranes have been previously reported. In this technology the layer-by-layer deposition also modifies membrane pores. Moreover, pH control is vital to achieving high swelling and creating membranes that capture large amounts of protein. High density functionalized membranes are devised at controlled pH and layer-by-layer deposition of the polymer results in unique porous structures, which may facilitate protein transport into the film for subsequent binding.

Key Benefits

• Simpler yet equally effective polymer adsorption compared to previously described methods
• Ease of implementation
• Cost effective

Applications

• Research and isolation of protein biotherapeutics
• Powerful tool for academic research

Patent Status: 

Issued US Patent US 10,773,217 and published patent application US20210001284A1 

Licensing Rights Available

Full licensing available

Inventors: Merlin Bruening, Salinda Wijeratne, Wenjing Ning, Jinlan Dong, Weijing Liu

Tech ID: TEC2015-0016