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Search Results - theresa+lansdell
Enhancement of Proteasome Activity for the Treatment of Neurodegenerative Diseases
Executive SummaryAs we age, a decrease in the 20S proteasome’s activity level yields an increase in the accumulation and aggregation of toxic proteins, which are the classical hallmarks of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Artificial activation of the proteasome leads to an...
New Quinoline-Based Proteasome Inhibitors
Executive SummaryThere are several existing cancer treatments that are effective at inducing cell death by decreasing proteasome activity: Velcade® (bortezomib) and Kyprolis® (carfilzomib). Due to undesirable side effects and pharmacodynamics properties, these agents have been limited to treating blood cancers. MSU researchers have developed...
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