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020009: Compositions and Methods for Epizootic Catarrhal Enteritis (ECE) Therapeutics and Diagnostics in Ferrets
In 1999, a coronavirus was identified as the cause of Epizootic Catarrhal Enteritis (ECE) in ferrets, a highly contagious diarrheal disease for which there are no effective diagnostics, therapeutics, or preventatives. This disease costs ferret breeders and owners millions of dollars a year in health care costs and lost revenue. In 1996, approximately...
Development of Diagnostic In-Situ Hybridization for a Commercial Platform
Executive Summary In situ hybridization (ISH) uses complementary DNA or RNA probes to localize a specific DNA or RNA sequence in in tissue sections. Because ISH targets nucleic acid sequences, as opposed to proteins, ISH can detect both expressed and unexpressed genes, making it a versatile and less costly diagnostic tool. As with other detection techniques,...
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