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Search Results - john+scott-craig
Cyclic Peptide Production Enzymes and System
Executive SummaryCyclic peptides tend to be resistant to peptidases and therefore stable in vivo. Their size, chemical properties, and ability to interact with biomolecules suggest that they make good pharmaceutical and agricultural active ingredient candidates. However, intra-molecular cyclization is difficult and competes with unwanted inter-molecular...
Alpha-Xylosidase: A New Enzyme for Enhancing Conversion of Lignocellulosic Biomass to Fermentable Sugars
Executive SummaryProducing cellulosic ethanol from biomass feedstock such as corn stover requires the breakdown of sturdy cell wall materials, including cellulose, hemicellulose, and lignin, into fermentable sugars. This breakdown is facilitated commercially by various enzyme cocktails. However, the high cost of enzymes has been a major barrier to...
Identification of the Gene for Amatoxin and Phallatoxin
Executive SummaryAmatoxins and phallotoxins, natural products found in poisonous mushrooms, are deadly in high concentrations. However, there is increased research activity to explore possible clinical applications of these toxins and other cyclic peptides. Because cyclic peptides have not been successfully produced in large amounts in the laboratory...
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