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Drug Combination Therapy to Eradicate Biofilm Formation
Executive SummaryBacterial biofilm formation is a major cause of morbidity and mortality in cystic fibrosis patients with pulmonary infections. The biofilm acts as a tough shield against the body’s own defense mechanisms and makes current antibiotic treatment extremely challenging, often resulting in a chronic, progressive course of the disease....
Anti-Biofilm Compound 1 (ABC-1) and Associated Derivative Molecules
IntroductionBacteria commonly attach to living and nonliving surfaces in the form of biofilms. In this morphology, the bacteria synthesize a matrix of extracellular polymeric substances (EPS) that provide the biofilm with protection and structural support. The EPS also gives the biofilm resistance to antibiotics and immune system clearance, making biofilms...
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