Process for the Preparation of a 1,5-Dideoxy-1, 5-Imino Hexitols from Oximes and Imines
Description of Technology
Michigan State University’s invention relates to a multi-step synthesis of a 1, 5-dideoxy-1, 5-imino hexitol from a ketoaldonic acid methyl ester of a hexose sugar with protected hydroxyl groups to novel intermediates. In particular, the invention relates to processes which enable the production of novel intermediates to the hexitol and, in particular, a ketoaldonic acid methyl ester oxime or alkylimine, which forms the ring structure of the hexitol by alternate routes.
U.S. patents 6,462,197; 6,590,121; 6,605,724; and 6,831,176
Rawle Hollingsworth, Gabriela Pistia-Brueggeman
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Michigan State University