Process for the Preparation of a 1,5-Dideoxy-1, 5-Imino Hexitols from Oximes and Imines


Description of Technology


Michigan State University’s invention relates to a multi-step synthesis of a 1, 5-dideoxy-1, 5-imino hexitol from a ketoaldonic acid methyl ester of a hexose sugar with protected hydroxyl groups to novel intermediates. In particular, the invention relates to processes which enable the production of novel intermediates to the hexitol and, in particular, a ketoaldonic acid methyl ester oxime or alkylimine, which forms the ring structure of the hexitol by alternate routes.


Patent Status


U.S. patents 6,462,197; 6,590,121; 6,605,724; and 6,831,176




Rawle Hollingsworth, Gabriela Pistia-Brueggeman


Tech ID




Patent Information:


For Information, Contact:

Thomas Herlache
Assistant Director
Michigan State University