Preparation of Hymenialdisine Derivatives and potential Application to Treatment of Inflammatory Diseases, Alzheimer's, and Cancer
Cyclin-dependent kinases and NF-kB regulate a large number of genes and biochemical pathways. Deviations in their activity are associated with diseases, including those linked to immune, inflammatory, and anti-apoptotic responses. Many areas of drug discovery are focused on discovery of reagents that inhibit their activities.
Naturally occurring compounds that are identified through marine biology represent a broad spectrum of potentially useful compounds. The multi-ring indolazepine derivatives described here are closely related to hymenialdisine compounds that have been isolated from marine sponges and are known to be potent kinase and NF-kB inhibitors.
Description of Technology
This technology consists of indolazepines, which are hymenialdisine-related compounds that inhibit NF-kB and cyclin-dependent kinases. These compounds have the potential for anti-inflammatory activity and inhibition of cancer cells. This invention describes in vitro biological activity and methods for synthesis and production of these unique indolazepine compounds.
- More potent inhibition of cyclin-dependent kinase and NF-KB activity: Will potentially lead to an effective inhibitor which has improved efficacy over hymenialdisine and other inhibitory molecules.
- Method for synthesis: Will provide the ability to produce pure, active material.
These compounds can potentially be used on their own, or in combination with complementary drugs or compounds in the treatment of a wide variety of medical conditions including inflammatory disorders such as arthritis, asthma, Alzheimer's, and cancers.
US 7335769 (issued Feb 26, 2008)
US 7193079 (issued Mar 20, 2007)
US 2004/0235820 A1 (filed Apr 28, 2004)
Alternative contact due to temporary leave:
Nina (Isi) Davis, Technology Marketing Manager, email: firstname.lastname@example.org, phone (direct): (517)884-1829.
For Information, Contact:
Michigan State University