Virus-Like Particle for Vaccine Development

 

Executive Summary

 

With the increasing attention on safety, vaccine development is more focused on targeting subunit epitopes. Thus, a suitable carrier that is capable of powerfully activate the immune system and elicit desired immune responses is critical. MSU researchers have developed new virus like particle (VLP) based platform technology, which can induce superior immune responses against the targeted epitopes compared to currently available protein carriers in the market. 

 

Description of Technology

 

This MSU technology is an enhanced VLP created to be a more powerful platform for vaccine development. When tested with an otherwise low immunogenic antigen, the modified VLP carrier induced a strong immune response while also significantly reducing anti-carrier antibodies. This technology is completely free of live virus and can be carried out by recombinant protein expression in E. coli, yeast, and cell-free protein synthesis, which provide flexibility in research and capacity in large-scale production.

 

Key Benefits

  • VLP capsid engineered to be more stable over current wild type platform.
  • Altered to reduce anti-carrier immune response.
  • Modified VLP platform customizable for differing types of antigens for vaccine constructs

 

Applications

  • Vaccine for cancer immunotherapy
  • Modified VLP is highly adaptable for use in many diseases/disorders (e.g. HIV, H1N1, allergic asthma, etc.)

 

Patent Status:

 

Under Review

 

Licensing Rights Available:

 

Full licensing rights available

 

Inventors: Xuefei Huang, Suttipun Sungsuwan

 

Tech ID: TEC2017-0099

 

Patent Information:

Category(s):

For Information, Contact:

SU-Jun Lim
Technology Manager
Michigan State University
limsuju1@msu.edu
Keywords: