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Novel Rexinoid Agonists for Kras-mediated cancer and immunotherapy

Executive Summary:KRAS is one of the most common oncogenes that, when mutated, causes normal cells to become cancerous. Current therapeutics designed to block KRAS function have not shown favorable clinical outcomes and therefore, KRAS has been deemed an “undruggable” target. However, our studies demonstrate that novel, appropriately substituted...
Published: 3/11/2020   |   Inventor(s): Karen Liby, Edmund Ellsworth, Ana Sofia Leal, Bilal Aleiwi
Keywords(s):   Category(s): Pharmaceutical, Therapeutic